93

93 Publications Verification

Synonyms: Calcein acetoxymethyl ester

Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .

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64

Prostaglandin E2

64 Cited Publications

Cat. No.: HY-101952

CAS No.: 363-24-6

Purity: 99.74%

Synonyms: PGE2; Dinoprostone

Category:

Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Endocrinology

Target:

Organoid Prostaglandin Receptor Endogenous Metabolite

Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

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56

Elexacaftor

56 Cited Publications

Cat. No.: HY-111772

CAS No.: 2216712-66-0

Purity: 99.74%

Synonyms: VX-445

Target:

CFTR Autophagy

Research Areas:

Inflammation/Immunology

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .

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55

OSMI-1

55 Cited Publications

Cat. No.: HY-119738

CAS No.: 1681056-61-0

Purity: 99.90%

Target:

OGT Acyltransferase

Research Areas:

Metabolic Disease

OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC₅₀ value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .

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48

Sulfosuccinimidyl oleate sodium

48 Cited Publications

Cat. No.: HY-112847A

Purity: ≥98.0%

Synonyms: Sulfo-N-succinimidyl oleate sodium

Target:

Mitophagy

Research Areas:

Inflammation/Immunology

Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect .

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35

Cyclo(-RGDfK)

35 Cited Publications

Cat. No.: HY-P0023

CAS No.: 161552-03-0

Target:

Integrin

Research Areas:

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC₅₀ of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

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35

Cyclo(-RGDfK) TFA

35 Cited Publications

Cat. No.: HY-P0023A

CAS No.: 500577-51-5

Target:

Integrin

Research Areas:

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the α_vβ₃ integrin, with an IC₅₀ of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .

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31

Tezacaftor

31 Cited Publications

Cat. No.: HY-15448

CAS No.: 1152311-62-0

Purity: 99.85%

Synonyms: VX-661

Target:

CFTR

Research Areas:

Cancer

Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

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30

β-Amyloid (1-42), human TFA

30 Cited Publications

Cat. No.: HY-P1363

Synonyms: Amyloid β-peptide (1-42) (human) TFA

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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30

β-Amyloid (1-42), human

30 Cited Publications

Cat. No.: HY-P1363A

CAS No.: 107761-42-2

Synonyms: Amyloid β-peptide (1-42) (human)

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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30

β-Amyloid (1-42), human, HFIP-treated

30 Cited Publications

Cat. No.: HY-P1363B

CAS No.: 107761-42-2

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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27

mPEG2000-DMG

27 Cited Publications

Cat. No.: HY-112764

CAS No.: 160743-62-4

Purity: 98.40%

Target:

Liposome

Research Areas:

Metabolic Disease

mPEG2000-DMG is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. mPEG2000-DMG is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles .

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25

Biotin NHS

25 Cited Publications

Cat. No.: HY-D0802

CAS No.: 35013-72-0

Synonyms: Biotin N-hydroxysuccinimide ester; NHS-Biotin

Biotin NHS is an amino reactive biotin reagent used in the preparation of biotinylated surfaces or polypeptides.

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24

Heparan Sulfate

24 Cited Publications

Cat. No.: HY-101916

CAS No.: 9050-30-0

Category:

Polysaccharides Neurological Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides

Target:

FGFR Wnt Endogenous Metabolite

Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.

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24

AZD-5991

24 Cited Publications

Cat. No.: HY-101533

CAS No.: 2143061-81-6

Purity: 99.79%

Target:

Bcl-2 Family

Research Areas:

Cancer

AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC₅₀ of 0.7 nM in FRET assay and a K_d of 0.17 nM in surface plasmon resonance (SPR) assay .

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