2

680C91

2 Cited Publications

Cat. No.: HY-108681

CAS No.: 163239-22-3

Purity: 99.54%

Target:

Collagen

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a K_i of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

LM10

1 Cited Publications

Cat. No.: HY-33298

CAS No.: 1316695-35-8

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Cancer

LM10 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO). Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that also degrades tryptophan along the kynurenine pathway. LM10 has the potential for the research of cancer diseases .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

IDO1/TDO-IN-4

1 Cited Publications

Cat. No.: HY-151108

CAS No.: 461424-21-5

Purity: 99.74%

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Neurological Disease Inflammation/Immunology

IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC₅₀ values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π−π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

IACS-8968

1 Cited Publications

Cat. No.: HY-112164

CAS No.: 2144425-14-7

Purity: 98.46%

Synonyms: IDO/TDO Inhibitor

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Cancer

IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC₅₀s of 6.43 for IDO and <5 for TDO, respectively.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

NU223612

Cat. No.: HY-151886

CAS No.: 2759420-43-2

Target:

PROTACs Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Neurological Disease Cancer

NU223612 is a cereblon (CRBN)-recruiting IDO1 PROTAC degrader, with a DC₅₀ value of 0.329-0.5438 μM against human IDO1, and it is capable of penetrating the blood-brain barrier. NU223612 directly binds to IDO1, mediates the degradation of both wild-type and catalytically inactive mutant IDO1 proteins, and does not degrade TDO2. NU223612 inhibits IDO1-mediated enzymatic activity. NU223612 directly binds to CRBN and promotes the formation of a cooperative ternary complex with IDO1. NU223612 induces ubiquitin-dependent proteasomal degradation of the IDO1 protein. NU223612 suppresses IDO1-mediated non-enzymatic phosphorylation of NF-κB p65 and the DNA-binding activity of downstream transcription factors. NU223612 can be used in studies of glioblastoma (malignant glioma) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

TDO-IN-1

Cat. No.: HY-151425

CAS No.: 2490672-92-7

Purity: 99.07%

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Cancer

TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over indoleamine-2,3-dioxygenase (IDO), with an IC₅₀ value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

IDO1/TDO-IN-9

Cat. No.: HY-177086

CAS No.: 1878200-88-4

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Cancer

IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) with IC₅₀s of <1 μM. IDO1/TDO-IN-9 inhibits the activity of IDO1 and TDO, blocking tryptophan degradation to kynurenine, restoring immune activity in the tumor microenvironment, and suppressing tumor growth. IDO1/TDO-IN-9 is promising for research of cancers .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

IDO/TDO-IN-1

Cat. No.: HY-128355

CAS No.: 2033173-01-0

Purity: 99.22%

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Cancer

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC₅₀s of 9.7 and 47 nM, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Amg-1

Cat. No.: HY-112867

CAS No.: 496023-55-3

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Amg-1 is a potent, reversible and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor (IC₅₀ = 3.0 μM). Amg-1 exhibits >80-fold selectivity over IDO2 (IC₅₀ > 250 μM) and >20-fold selective over TDO (IC₅₀ > 62.5 μM). Amg-1 can be used for cancer, hypotension, and neurological disorders research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

TDO2-IN-1

Cat. No.: HY-170322

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Metabolic Disease Cancer

TDO2-IN-1 is a selective TDO2 inhibitor. TDO2-IN-1 binds to the active pocket, heme-binding pocket and substrate-binding pocket of apo-TDO2, interacts with key residues, competitively inhibits heme insertion, and suppresses intracellular TDO2 activity. TDO2-IN-1 can be used in research related to cancer, metabolism and other fields .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Dihydroanthracene

Cat. No.: HY-W103225

CAS No.: 613-31-0

Target:

Bacterial

Research Areas:

Infection

Dihydroanthracene (9,10-Dihydroanthracene) is a substrate for toluene dioxygenase (TDO) expressed by Pseudomonas putida UV4. Toluene dioxygenase (TDO) expressed by Pseudomonas putida UV4 catalyzes the benzylic monooxygenation of Dihydroanthracene to 9-hydroxy-9,10-DHA as the only product .

Compare

loading...