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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
TRPML3
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "TRPML3" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-16696
CAS No.: 823218-99-1
Target:
Research Areas:
SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM .
SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) .
4
4 Cited Publications
Synonyms: (-)-trans-ML-SI3
Target:
Research Areas:
(1R,2R)-ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R)-ML-SI3 inhibits TRPMLs with IC50s of 1.6 μM (TRPML1), 2.3 μM (TRPML2), and 12.5 μM (TRPML3), respectively .
2
2 Cited Publications
Synonyms: trans-ML-SI3
Target:
Research Areas:
(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM) [3].
Synonyms: (+)-trans-ML-SI3
Target:
Research Areas:
(1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM) .
Cat. No.: HY-W008581
CAS No.: 1035-77-4
Synonyms: 3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol
Research Areas:
Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC50 values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC50 of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer .
Cat. No.: HY-187969
CAS No.: 2742654-01-7
Target:
Research Areas:
EVP-21 is a selective TRPML3 agonist with an EC50 of 4.3 μM for human TRPML3. EVP-21 elicits TRPML3 currents in late endosomes/lysosomes and early endosomes. EVP-21 can be used for research on TRPML3-related mechanisms such as emphysema, hearing loss, and yellow fever virus infection .
Cat. No.: HY-RS08246
Target:
Research Areas:
MCOLN3 Human Pre-designed siRNA Set A contains three designed siRNAs for MCOLN3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
