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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
UAF1
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "UAF1" in MCE Product Catalog:
20
20 Publications Verification
Cat. No.: HY-17543
CAS No.: 1572414-83-5
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ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM.
5
5 Cited Publications
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SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM.
3
3 Cited Publications
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C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
1
1 Cited Publications
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I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells [1].
Cat. No.: HY-RS15784
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WDR48 Human Pre-designed siRNA Set A contains three designed siRNAs for WDR48 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-161446
CAS No.: 3033480-42-8
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USP1-IN-7 (Compound 3) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC50 ≤50 nM. USP1-IN-7 inhibits proliferation of MDA-MB-436 with IC50 ≤50 nM [1].
Cat. No.: HY-161447
CAS No.: 3033480-77-9
Cat. No.: HY-162633
CAS No.: 2925548-22-5
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USP1-IN-9 (Compound 1m) is reversible and noncompetitive ubiquitin-specific proteases (USP1) inhibitors with an IC50 of 8.8 nM, which is designed and synthesized to pyrido[2,3-d]pyrimidin-7(8H)-one derivative based on the disclosed structure of ML323(HY-17543) and KSQ-4279(HY-145471). USP1-IN-9 displays excellent USP1/UAF inhibition and exhibits strong antiproliferation effect in breast cancer cells. USP1-IN-9 can generate enhanced cell killing with PARP inhibitor olaparib(HY-10162) in olaparib-resistant MDA-MB-436/OP cells, which is promising for research in the field of cancer [1].
Cat. No.: HY-181702
CAS No.: 3084671-46-2
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USP1-IN-16 is a USP1 inhibitor with an USP1-UAF1 IC50 value of 0.002 μM. USP1-IN-16 can be used in the research of USP1-related malignancies [1].
Cat. No.: HY-187468
CAS No.: 3068739-67-0
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USP1-IN-19 is a USP1 inhibitor with an IC50 of 0-50 nM in the USP1-UAF1 deubiquitination assay. USP1-IN-19 exhibits dose-dependent antitumor effects against non-small cell lung cancer and breast cancer. USP1-IN-19 can be used for cancer research [1].
Cat. No.: HY-183581
CAS No.: 3064481-29-1
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USP1-IN-18 is an orally active USP1 inhibitor with a human IC50 of 17.0 nM. USP1-IN-18 inhibits USP1-UAF1 deubiquitinase activity and drives ubiquitinated PCNA accumulation. USP1-IN-18 induces DNA damage, replication stress, and G2-M phase cell cycle arrest. USP1-IN-18 can be used for the research of triple-negative breast cancer [1].
Cat. No.: HY-189455
CAS No.: 3094127-54-2
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USP1-IN-20 is an orally effective and selective USP1 inhibitor with an IC50 of 3.0 nM. USP1-IN-20 inhibits the USP1-UAF1 complex, leading to the accumulation of Ub-PCNA, which in turn induces DNA damage and G2/M phase arrest, while simultaneously promoting the degradation of the oncogenic protein c-MYC. USP1-IN-20 can be used for research on breast cancer and diffuse large B-cell lymphoma [1].
Cat. No.: HY-183363
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USP1-IN-17 is an orally active USP1/UAF1 complex inhibitor. USP1-IN-17 exhibits potent anti-proliferative activity against BRCA1-mutant human breast cancer MDA-MB-436 cells, with an IC50 value of 8.1 nM. USP1-IN-17 binds to USP1 to stabilize the enzyme conformation, impairs deubiquitination function, elevates the monoubiquitination level of PCNA, inhibits cancer cell proliferation, and induces DNA damage accumulation. USP1-IN-17 can be used for the research of BRCA1-mutated cancers [1].
Cat. No.: HY-RS22921
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Research Areas:
Wdr48 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wdr48 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
