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65 Results for "

Unfolded

" in MedChemExpress (MCE) Product Catalog:

Products (65)

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183

Tunicamycin

183 Publications Verification

Cat. No.: HY-A0098

CAS No.: 11089-65-9

Category:

Antifungal Disease Research Antibacterial Other Antibiotics Infection Microorganisms Antibiotics Antiviral Anticancer Disease Research Fields Inflammation/Immunology

Target:

Antibiotic Influenza Virus Fungal Bacterial Aminotransferases (Transaminases) Exosomes

Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity .Tunicamycin increases exosome release in cervical cancer cells .

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TPE-MI

18 Cited Publications

Cat. No.: HY-143218

CAS No.: 1245606-71-6

Purity: 98.05%

Synonyms: Tetraphenylethene maleimide

TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasites Plasmodium falciparum .

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IXA4

13 Cited Publications

Cat. No.: HY-139214

CAS No.: 1185329-96-7

Purity: 98.83%

Target:

IRE1

Research Areas:

Neurological Disease

IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways (e.g., the heat shock response or oxidative stress response). IXA4 reduces secretion of APP through IRE1 activation .

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Azoramide

7 Cited Publications

Cat. No.: HY-18705

CAS No.: 932986-18-0

Target:

Apoptosis Reactive Oxygen Species (ROS) Caspase Bcl-2 Family Mitochondrial Metabolism

Research Areas:

Endocrinology

Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity .

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