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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
V-ATPase
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "V-ATPase" in MCE Product Catalog:
952
952 Publications Verification
Synonyms: BafA1
Category:
Infection Macrolide Antibiotics Antibiotics Microorganism Disease Research Anticancer Disease Research Fields
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30
30 Cited Publications
Cat. No.: HY-N1724
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B; Folimycin; X 4357B
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30
30 Cited Publications
Cat. No.: HY-N1724A
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)
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6
6 Cited Publications
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EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner .
4
4 Cited Publications
Cat. No.: HY-N2532
CAS No.: 22055-22-7
Category:
Lignans Infection Plant Monophenols Dysosma versipellis (Hance) M. Cheng ex Ying Extract Phenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Berberidaceae Extract
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4
4 Cited Publications
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KM91104 is a cell-permeable V-ATPase a3-b2 inhibitor (IC50 = 2.3 µM). KM91104 reduces the metabolic activity, cell proliferation capacity and V-ATPase subunit protein expression levels of primary human hepatic stellate cells, increases intracellular ATP levels and decreases cytoplasmic pH. KM91104 reduces TLR4 expression on the surface of oligodendrocyte precursor cells, blocks the ENV-TLR4 interaction, and reverses oligodendrocyte myelination defects induced by ENV protein .
1
1 Cited Publications
Category:
Infection Macrolide Antibiotics Antibiotics Microorganism Disease Research Antibacterial Anticancer Disease Research Fields Cancer
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1
1 Cited Publications
Cat. No.: HY-N6738
CAS No.: 88899-56-3
Category:
Infection Macrolide Antibiotics Antibiotics Microorganism Disease Research Antibacterial Disease Research Fields
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Cat. No.: HY-P2657
CAS No.: 138067-14-8
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Cat. No.: HY-176954
CAS No.: 2171015-78-2
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RSC-1255 is a potent and selective Vacuolar H⁺-ATPase (V-ATPase) inhibitor that directly binds the mammalian V-ATPase complex with a Kd = 23 nM. RSC-1255 exhibits preferential cytotoxicity toward KRAS-mutant cancer cells, especially KRAS G13D and KRAS G12V cells. RSC-1255 induces apoptosis and blocks lysosomal acidification, autophagy, and macropinocytosis in cancer cells. RSC-1255 can be used for the study of KRAS-driven lung and colon cancers .
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Aldolase, Rabbit muscle (Fructose-diphosphate aldolase) is a glycolytic enzyme and glucose availability sensor. Aldolase, Rabbit muscle catalyzes the reversible carbon-carbon cleavage of fructose-1,6-bisphosphate to produce dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase, Rabbit muscle is an essential component for v-ATPase activity. Aldolase, Rabbit muscle participates in processes such as gluconeogenesis, the Calvin cycle and glycolysis .
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Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex .
Cat. No.: HY-162935
CAS No.: 1243603-61-3
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V-ATPase-IN-1 (Compound 3b-03) is a Vacuolar-type H +-ATPases (V-ATPase) inhibitor (IC50 = 194.80 μM) that can effectively target the V-ATPase subunit A (Kd = 0.803 μM). V-ATPase-IN-1 exhibits insecticidal activity against M. separata (LC50 = 2.64 mM) and contributes to research in the development of chemical insecticides .
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Cat. No.: HY-162264
CAS No.: 3032401-72-9
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Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration .
Cat. No.: HY-W436428
CAS No.: 69570-95-2
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V-161 is the orally active inhibitor for Na +-V-ATPase with an IC50 of 144 nM. V-161 inhibits Enterococcus hirae and Vancomycin-resistant Enterococcus faecium (VRE) under alkaline condition with MIC of 4 µg/mL and 4 µg/mL. V-161 inhibits colonization of VRE in mouse small intestine .
Cat. No.: HY-123095
CAS No.: 1314486-37-7
Synonyms: JBIR 100
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Cat. No.: HY-N12413
CAS No.: 220757-06-2
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Cat. No.: HY-183975
V-ATPase-IN-2 is an inhibitor targeting the a-c subunits of vacuolar H +-ATPase (V-ATPase), with an EC50 of 8.449 μg/mL against Phytophthora capsici. V-ATPase-IN-2 causes significant vacuolar enlargement and ultrastructural damage in Phytophthora capsici cells, and also inhibits sporangium formation, zoospore release, and cyst germination of this pathogen. V-ATPase-IN-2 can be used in studies related to Phytophthora capsici infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
