Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
WRN helicase function
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "WRN helicase function" in MCE Product Catalog:
Cat. No.: HY-169422
CAS No.: 3064599-36-3
Synonyms: IDE275
Target:
Research Areas:
GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC) .
Cat. No.: HY-169422A
CAS No.: 3064599-37-4
Synonyms: IDE275 (enantiomer)
Target:
Research Areas:
GSK4418959 enantiomer is an enantiomer of GSK4418959 (HY-169422). GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .
Cat. No.: HY-168934
Target:
Research Areas:
KWR137 is an orally active Werner protein (WRN) inhibitor with a human IC50 of 8 nM. KWR137 inhibits the ATPase activity required for WRN helicase function, induces WRN protein degradation, suppresses cancer cell proliferation, and slows tumor growth without causing weight loss or off-target effects. KWR137 can be used for the research of colorectal cancer .
Cat. No.: HY-176727
Target:
Research Areas:
WRN inhibitor 19 (Compound 40) is a WRN helicase inhibitor (IC50: 3.7 nM). WRN inhibitor 19 exhibits selective antiproliferative activity in WRN-dependent cancer cells. WRN inhibitor 19 inhibits WRN helicase function by competitively binding to the ATP site and induces DNA damage and cell cycle arrest. WRN inhibitor 19 can be used in the study of WRN-dependent cancers .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
