63

Emricasan

63 Publications Verification

Cat. No.: HY-10396

CAS No.: 254750-02-2

Purity: 99.81%

Synonyms: PF 03491390; IDN-6556

Target:

Caspase Flavivirus

Research Areas:

Infection Neurological Disease Cancer

Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors .

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36

Pyridostatin TFA

36 Cited Publications

Cat. No.: HY-15176B

CAS No.: 1472611-44-1

Purity: 99.54%

Synonyms: RR82 TFA

Target:

DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease

Research Areas:

Cancer

Pyridostatin (RR82) TFA is a G-quadruplex (G4) inducer/stabilizer with a K_d of 490 nM. Pyridostatin TFA also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 11.0 μM. Pyridostatin TFA interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin TFA exhibits antiproliferative and antiviral activities. Pyridostatin TFA can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .

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36

Pyridostatin trihydrochloride

36 Cited Publications

Cat. No.: HY-15176C

CAS No.: 2517456-88-9

Synonyms: RR82 trihydrochloride

Target:

DNA/RNA Synthesis G-quadruplex Flavivirus Src Virus Protease

Research Areas:

Cancer

Pyridostatin (RR82) trihydrochloride is a G-quadruplex (G4) inducer/stabilizer with a K_d of 490 nM. Pyridostatin trihydrochloride also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 11.0 μM. Pyridostatin trihydrochloride interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin trihydrochloride exhibits antiproliferative and antiviral activities. Pyridostatin trihydrochloride can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .

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11

ML-SA1

11 Cited Publications

Cat. No.: HY-108462

CAS No.: 332382-54-4

Purity: 99.44%

Target:

Dengue Virus TRP Channel Flavivirus

Research Areas:

Infection

ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC₅₀ value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .

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10

Theaflavin 3,3'-digallate

10 Cited Publications

Cat. No.: HY-N1992

CAS No.: 30462-35-2

Synonyms: TF-3; ZP10

Category:

Infection Flavonoids Flavanols Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Theaceae Extract

Target:

Virus Protease HSV HIV Flavivirus

Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

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5

SN 2

5 Cited Publications

Cat. No.: HY-16696

CAS No.: 823218-99-1

Target:

Flavivirus Dengue Virus TRP Channel

Research Areas:

Infection

SN 2 is a potent activator of TRPML3 ion channel with an EC₅₀ of 1.8 μM . SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) .

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4

PKI 14-22 amide,myristoylated

4 Cited Publications

Cat. No.: HY-P1291

CAS No.: 201422-03-9

Target:

PKA Epigenetic Reader Domain Flavivirus

Research Areas:

Infection Neurological Disease

PKI 14-22 amide, myristoylated is a selective, cAMP-dependent, competitive PKA inhibitor with K_i=~36 nM. The myristoylation modification of PKI 14-22 amide, myristoylated makes it more permeable to cell membranes and blood-brain barriers than the precursor molecule. PKI 14-22 amide, myristoylated can block the phosphorylation of cAMP-dependent downstream targets (such as CREB). PKI 14-22 amide, myristoylated can prevent the development of morphine analgesic tolerance in mice, and also inhibits protein translation and negative-strand RNA synthesis of Zika virus. PKI 14-22 amide, myristoylated can be used in research fields such as opioid tolerance mechanisms and antiviral drugs .

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4

PKI 14-22 amide,myristoylated TFA

4 Cited Publications

Cat. No.: HY-P1291A

Target:

PKA Epigenetic Reader Domain Flavivirus

Research Areas:

Infection Neurological Disease

PKI 14-22 amide, myristoylated TFA is a selective, cAMP-dependent, competitive PKA inhibitor with K_i=~36 nM. The myristoylation modification of PKI 14-22 amide, myristoylated TFA makes it more permeable to cell membranes and blood-brain barriers than the precursor molecule. PKI 14-22 amide, myristoylated TFA can block the phosphorylation of cAMP-dependent downstream targets (such as CREB). PKI 14-22 amide, myristoylated TFA can prevent the development of analgesic tolerance in mice, and also inhibits protein translation and negative-strand RNA synthesis of Zika virus. PKI 14-22 amide, myristoylated TFA can be used in research fields such as opioid tolerance mechanisms and antiviral drugs .

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3

Nanchangmycin

3 Cited Publications

Cat. No.: HY-100528

CAS No.: 65101-87-3

Purity: 99.67%

Synonyms: Nanchangmycin A

Category:

Infection Microorganisms Antibiotics Antiviral Disease Research Antibacterial Disease Research Fields Polyether Antibiotics

Target:

Bacterial Antibiotic Flavivirus

Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria . Nanchangmycin is a broad spectrum antiviral active against Zika virus .

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3

Dianemycin

3 Cited Publications

Cat. No.: HY-100528A

CAS No.: 35865-33-9

Purity: 99.67%

Synonyms: Nanchangmycin free acid

Category:

Infection Microorganisms Antibiotics Antiviral Disease Research Antibacterial Disease Research Fields Polyether Antibiotics

Target:

Bacterial Antibiotic Flavivirus

Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria . Nanchangmycin is a broad spectrum antiviral active against Zika virus .

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2

Palonosetron hydrochloride

2 Cited Publications

Cat. No.: HY-A0021

CAS No.: 135729-62-3

Target:

5-HT Receptor Flavivirus

Research Areas:

Infection Cardiovascular Disease Neurological Disease

Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity .

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2

Cephaeline

2 Cited Publications

Cat. No.: HY-N4118

CAS No.: 483-17-0

Synonyms: (-)-Cephaeline; NSC 32944 free base

Category:

Infection Alkaloids Monophenols Phenols Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids

Target:

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline ((-)-Cephaeline; NSC 32944) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline inhibits cancer cell proliferation, migration and tumor growth. Cephaeline inhibits Ebola virus (EBOV) VLP entry and infection, with IC₅₀ values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC₅₀ = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with K_d values of 8.9 μM and 53.8 μM respectively. Cephaeline can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .

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2

Temephos

2 Cited Publications

Cat. No.: HY-B1120

CAS No.: 3383-96-8

Synonyms: Temefos

Target:

Insecticide Cholinesterase (ChE) Dengue Virus Flavivirus

Research Areas:

Infection

Temephos (Temefos) is an orally active, blood-brain barrier-permeable organophosphate insecticide and AChE inhibitor. By irreversibly inhibiting AChE to induce cholinergic overactivation, Temephos effectively blocks larval development of Aedes aegypti (yellow fever mosquito) and Aedes albopictus (Asian tiger mosquito), and is commonly used in studies related to Dengue Virus, Zika Virus and other relevant pathogens. Temephos exhibits genotoxicity and neurodevelopmental toxicity, and may also cause liver injury, reproductive system abnormalities and cholinergic poisoning symptoms in mammals. Temephos tends to accumulate in adipose tissues and aquatic organisms, and is excreted via feces after metabolism through oxidation and hydrolysis. Note that CYP-mediated metabolic detoxification may reduce the actual larvicidal efficacy of Temephos against some mosquito species. Temephos can be used in research related to dengue fever, Zika virus disease, chikungunya and dracunculiasis .

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2

Cephaeline hydrochloride

2 Cited Publications

Cat. No.: HY-N2076

CAS No.: 3738-70-3

Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride

Category:

Infection Alkaloids Monophenols Phenols Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids

Target:

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline hydrochloride ((-)-Cephaeline (hydrochloride); NSC 32944 (monohydrochloride)) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline hydrochloride induces Ferroptosis by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline hydrochloride inhibits cancer cell proliferation, migration and tumor growth. Cephaeline hydrochloride inhibits Ebola virus (EBOV) VLP entry and infection, with IC₅₀ values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC₅₀ = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with K_d values of 8.9 μM and 53.8 μM respectively. Cephaeline hydrochloride can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .

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