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THIP

1 Cited Publications

Cat. No.: HY-10232

CAS No.: 64603-91-4

Purity: 99.93%

Synonyms: Gaboxadol

Target:

GABA Receptor

Research Areas:

Neurological Disease

THIP (Gaboxadol) is a blood-brain barrier-penetrant, orally active selective GABA_A receptor agonist. THIP exhibits EC₅₀ values of 33 μM and 130 μM for α₄β₂δ and α₄β₁δ receptors, respectively. THIP activates extrasynaptic GABA_A receptors to produce tonic inhibition and inhibits GABAergic interneurons to cause disinhibition. THIP is used in research on insomnia, sleep disorders, and addictive behaviors .

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U-69593

1 Cited Publications

Cat. No.: HY-12363

CAS No.: 96744-75-1

Purity: 99.73%

Target:

Opioid Receptor

Research Areas:

Neurological Disease

U-69593 is a potent and selective κ1-opioid receptor agonist . U-69593 attenuates addictive agent-induced behavioral sensitization in the rat . U-69593 reduces anxiety and enhances spontaneous alternation memory in mice . U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum .

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CB1 antagonist 2

1 Cited Publications

Cat. No.: HY-116649

CAS No.: 614726-85-1

Purity: 99.91%

Synonyms: AM4113

Target:

Cannabinoid Receptor

Research Areas:

Neurological Disease Metabolic Disease

CB1 antagonist 2 (AM4113) is an orally active cannabinoid receptor type 1 (CB1R) antagonist. CB1 antagonist 2 suppresses appetite, reduces body weight, and blocks addictive behaviors such as heroin addiction, without causing adverse effects like nausea and depression that are associated with traditional CB1 inverse agonists. CB1 antagonist 2 can be used in studies related to obesity and opioid addiction .

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AT-121

Cat. No.: HY-112692

CAS No.: 2099681-31-7

Purity: ≥96.0%

Target:

Opioid Receptor

Research Areas:

Neurological Disease

AT-121 is a bifunctional nociception and mu opioid receptor agonist, with K_is of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects .

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Zolunicant

Cat. No.: HY-147428

CAS No.: 188125-42-0

Purity: 99.29%

Synonyms: MM-110; (±)-18-Methoxycoronaridine

Target:

nAChR Parasite

Research Areas:

Infection Neurological Disease

Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC₅₀ of 0.90 μM to combat addiction. Zolunicant can decrease the self-administration of several addictive agents including morphine, methamphetamine, nicotine, and ethanol in rat model. Zolunicant can be studied as a potential research for multiple forms of agent abuse . Zolunicant also reveals a potent leishmanicide effect against Leishmania amazonensis .

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PF-04455242

Cat. No.: HY-15691

CAS No.: 1202647-54-8

Target:

Opioid Receptor mTOR

Research Areas:

Neurological Disease Metabolic Disease

PF-04455242 is an orally bioavailable, blood-brain barrier-permeable κ-opioid receptor (KOR) inhibitor. PF-04455242 blocks in vivo effects induced by KOR and MOR agonists, and elicits KOR-independent outward currents in ventral tegmental area neurons. PF-04455242 promotes energy expenditure and activates the hypothalamic mTOR pathway. PF-04455242 attenuates stress-induced behavioral effects and produces antidepressant-like effects. PF-04455242 can be used in studies related to pain, depression, addictive disorders, and obesity induced by estrogen withdrawal .

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(-)-Isocorypalmine

Cat. No.: HY-N0927

CAS No.: 483-34-1

Synonyms: Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine

Category:

Alkaloids Monophenols Other Diseases Phenols Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids

Target:

Dopamine Receptor

(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research .

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[Glp5,(Me)Phe8,Sar9] Substance P (5-11)

Cat. No.: HY-P3801

CAS No.: 77128-69-9

Synonyms: DiMe-C7

Target:

Neurokinin Receptor

Research Areas:

Neurological Disease Metabolic Disease

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .

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