Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
adrenoleukodystrophy
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "adrenoleukodystrophy" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: Tetracosanoic acid
Category:
Target:
2
2 Cited Publications
Target:
Research Areas:
ELOVL1-IN-3 (Compound 22) is a potent and orally active inhibitor of elongation of very long chain fatty acid 1 (ELOVL1) enzyme. ELOVL1-IN-3 serves as a useful tool for researching adrenoleukodystrophy (ALD) [1].
2
2 Cited Publications
Target:
Research Areas:
ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD) .
1
Category:
Cardiovascular Disease Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-160004
CAS No.: 1523493-53-9
Target:
PXL770 is an orally active, direct allosteric AMP-activated protein kinase (AMPK) activator. PXL770 decreases C26:0 levels, improves mitochondrial respiration, reduces expression of proinflammatory genes and induces expression of compensatory transporters (ABCD2/3) in ALD fibroblasts/lymphocytes. PXL770 normalizes plasma VLCFA levels, significantly reduces elevated VLCFA levels in brain and spinal cord in Abcd1 KO mice. PXL770 improves glycemia, dyslipidemia, and insulin resistance in ob/ob and high-fat diet (HFD)-fed mice. PXL770 can be used for the study of X-linked adrenoleukodystrophy (ALD), autosomal dominant polycystic kidney disease and nonalcoholic steatohepatitis (NASH) .
Cat. No.: HY-160207
CAS No.: 2156649-32-8
Synonyms: MA-JD21; ABX-002
Research Areas:
Elunetirom (MA-JD21) is an orally active, blood-brain barrier-permeable prodrug of LL-340001. Elunetirom employs fatty acid amide hydrolase (FAAH)-dependent prodrug technology to enhance the brain delivery of LL-340001, a potent thyroid hormone receptor agonist with 15-fold higher selectivity for TRβ over TRα. Elunetirom induces T3-regulated gene expression, including that of ABCD2. Elunetirom drives neuroplasticity and bioenergetic changes, and induces neurogenesis, neuritogenesis, and synaptogenesis. Elunetirom is applicable to research related to major depressive disorder and X-linked adrenoleukodystrophy .
Target:
Research Areas:
VK-0214 is an orally effective agonist of the thyroid β receptor (TRβ). VK-0214 reduces the accumulation of very long-chain fatty acids (VLCFA) by activating ABCD2 expression. VK-0214 has the effect of regulating fatty acid metabolism. VK-0214 can serve as a GBM repurposing candidate compound identified through network pharmacology screening. VK-0214 can be used in research related to X-linked adrenoleukodystrophy (X-ALD) and glioblastoma .
Synonyms: Tetracosanoic acid-d47
Synonyms: Tetracosanoic acid-d4-2
Synonyms: Tetracosanoic acid-d3
Target:
Research Areas:
Lignoceric acid-d3 is the deuterium labeled Lignoceric acid . Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research .
Cat. No.: HY-113301R
CAS No.: 506-46-7
Cat. No.: HY-113301S
CAS No.: 1208837-79-9
Cat. No.: HY-113301S2
CAS No.: 2692624-17-0
Research Areas:
Hexacosanoic acid-d3 is deuterium labeled Hexacosanoic acid (HY-113301). Hexacosanoic acid is a very long-chain fatty acid. Abnormally elevated levels of Hexacosanoic acid are closely associated with various diseases, such as X-linked adrenoleukodystrophy, adrenomyeloneuropathy, atherosclerosis, and dementia .
Cat. No.: HY-W331017
CAS No.: 1213783-80-2
Synonyms: 26:0 Lyso PC
Target:
Research Areas:
1-Hexacosanoyl-sn-glycero-3-phosphocholine (26:0 Lyso PC) is a long-chain fatty acid. 1-Hexacosanoyl-sn-glycero-3-phosphocholine can be used as a biomarker for X-linked adrenoleukodystrophy (ALD) in mice .
Cat. No.: HY-121883R
CAS No.: 557-59-5
Synonyms: Tetracosanoic acid (Standard)
Category:
Cat. No.: HY-115706
CAS No.: 120639-92-1
Synonyms: 1,3-Ditetracosanoin
Target:
Research Areas:
13-Dilignoceroyl glycerol is a diacylglycerol containing lignoceric acid (HY-121883 ) at the sn-1 and sn-3 positions. Lignoceric acid is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro-hepato-renal syndrome and adrenoleukodystrophy research .
Cat. No.: HY-121883S2
CAS No.: 61389-26-2
Synonyms: Tetracosanoic acid-d4
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
