6

Danicopan

6 Cited Publications

Cat. No.: HY-117930

CAS No.: 1903768-17-1

Purity: 99.91%

Synonyms: ACH-4471

Target:

Complement System

Research Areas:

Inflammation/Immunology

Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K_d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

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1

21-Deoxycortisol

1 Cited Publications

Cat. No.: HY-113405

CAS No.: 641-77-0

Purity: 99.62%

Category:

Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:

Endogenous Metabolite

21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD) .

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Pelecopan

Cat. No.: HY-147297

CAS No.: 2378380-49-3

Purity: 98.13%

Synonyms: BCX9930

Target:

Complement System

Research Areas:

Inflammation/Immunology

Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC₅₀ value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases .

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Crovalimab

Cat. No.: HY-P99965

CAS No.: 1917321-26-6

Synonyms: SKY59; RO7112689; RG-6107

Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .

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Zaltenibart

Cat. No.: HY-P990952

CAS No.: 2527079-60-1

Synonyms: OMS906

Zaltenibart (OMS906) is an IgG4 humanized monoclonal antibody and MASP-3 inhibitor. By inhibiting MASP-3, Zaltenibart achieves upstream inhibition of the alternative complement pathway. MASP-3 is an upstream activator of Factor D (Factor D), a key enzyme in the alternative complement pathway. Zaltenibart prevents both intravascular hemolysis and extravascular hemolysis. Zaltenibart is applicable to research related to paroxysmal nocturnal hemoglobinuria .

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FD-IN-1

Cat. No.: HY-128570

CAS No.: 1646682-14-5

Purity: 99.24%

Target:

Complement System

Research Areas:

Inflammation/Immunology

FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC₅₀ of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC₅₀s of 7.7 and 6.5 µM, respectively .

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Tyk2-IN-7

Cat. No.: HY-126242S

CAS No.: 1609391-90-3

Purity: 99.62%

Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC₅₀ and K_i.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the IL-23 and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis .

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Ianalumab (FUT8-KO)

Cat. No.: HY-P99653A

Synonyms: VAY-736 (FUT8-KO)

Ianalumab (VAY-736) (FUT8-KO) is an anti-BAFF-R monoclonal antibody expressed in CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose depletion enhances its B cell clearance capacity. Ianalumab (FUT8-KO) competitively blocks the binding of BAFF to BAFF-R, inhibits the BAFF-mediated alternative NF-κB pro-survival signaling pathway, and abrogates the apoptotic (apoptosis) protective effect of BAFF on cancer cells. Ianalumab (FUT8-KO) can be used in research related to primary Sjögren's syndrome and chronic lymphocytic leukemia .

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Lampalizumab

Cat. No.: HY-P99298

CAS No.: 1278466-20-8

Synonyms: RG 7417; TNX 234; Anti-CFD Recombinant Antibody

Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

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AZD3470

Cat. No.: HY-158143

CAS No.: 2918814-97-6

Target:

Histone Methyltransferase Apoptosis

Research Areas:

Cancer

AZD3470 is an orally active MTA-cooperative PRMT5 inhibitor, selective for MTAP-deficient tumors. AZD3470 induces cell cycle G₂/M phase alterations, DNA damage, apoptosis, and symmetric dimethylarginine reduction. AZD3470 alters alternative splicing, increases skipped exon events in DNA repair and cell cycle pathways, and inhibits cancer cell proliferation and tumor growth. AZD3470 can be used for the research of non-small cell lung cancer and MTAP-deleted solid tumors .

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Complement factor D-IN-2

Cat. No.: HY-138281

CAS No.: 1903742-34-6

Purity: 99.33%

Target:

Complement System

Research Areas:

Inflammation/Immunology

Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. Complement factor D-IN-2 can be used for the research of autoimmune diseases .

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21-Deoxycortisol (Standard)

Cat. No.: HY-113405R

CAS No.: 641-77-0

Category:

Endogenous metabolite Steroids

Target:

Reference Standards Endogenous Metabolite

21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol (HY-113405). This product is intended for research and analytical applications. 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD) .

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PRT543

Cat. No.: HY-141876

CAS No.: 2278356-90-2

Target:

Histone Methyltransferase Notch PI3K Akt Bcl-2 Family DNA/RNA Synthesis

Research Areas:

Cancer

PRT543 is an orally active selective PRMT5 inhibitor. PRT543 reduces intracellular symmetric dimethylarginine (sDMA) levels, downregulates the expression of genes related to DNA damage repair and DNA replication pathways, and induces abnormal alternative splicing. PRT543 inhibits the MYB, NOTCH1 and PI3K/AKT signaling pathways, promotes nuclear translocation of FOXO1, upregulates the pro-apoptotic protein BAX, and enhances cellular sensitivity to BCL-2 inhibition. PRT543 disrupts the normal RNA splicing process and exerts a synthetic lethal effect on myeloid tumor cells carrying splicing factor mutations. PRT543 can be used in research related to various cancers including breast cancer, ovarian cancer and acute myeloid leukemia .

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