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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
anthranilate
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "anthranilate" in MCE Product Catalog:
Cat. No.: HY-W142073
CAS No.: 17332-70-6
Synonyms: 7-Methyltryptophan
Target:
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an anthranilate synthase inhibitor that inhibits tryptophan biosynthesis. 7-Methyl-DL-tryptophan is also a tryptophan analog. 7-Methyl-DL-tryptophan can cause growth inhibition in tobacco, whereas a feedback-insensitive anthranilate synthase confers resistance and can be used as a selective agent to recover transgenic tobacco plants expressing this enzyme .
Target:
Amino Acid Derivatives Toll-like Receptor (TLR) MyD88 NF-κB Interleukin Related TNF Receptor Bacterial
Research Areas:
5-Methyl-DL-tryptophan is an orally active amino acid derivative with anti-inflammatory signaling effects. 5-Methyl-DL-tryptophan inhibits TLR4/MyD88 signaling and NF-κB activation/phosphorylation, reduces IL-6/IL-1β/TNF-α, and decreases the p-p65/p65 ratio. 5-Methyl-DL-tryptophan inhibits anthranilate synthase (Ki = 13 μM). 5-Methyl-DL-tryptophan inhibits bacterial growth. 5-Methyl-DL-tryptophan can be used in research on ulcerative colitis .
Cat. No.: HY-76705S
CAS No.: 2562378-12-3
Target:
Isotope-Labeled Compounds Bacterial DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Methyl N-methylanthranilate-d3 is the deuterated-labeled Methyl N-methylanthranilate (HY-76705). Methyl N-methylanthranilate is an N-alkylated anthranilate with a sweet citrus aroma, which is commonly used in perfume manufacturing. Methyl N-methylanthranilate is the dominant component in the defensive secretion of the millipede Typhloiulus orpheus. Methyl N-methylanthranilate exhibits quorum sensing inhibition and anti-biofilm activity against P. aeruginosa; it interferes with PQS synthesis via competitive inhibition of PqsA, but lacks bactericidal activity. Methyl N-methylanthranilate is sensitive to UVA/sunlight in human skin cells, and generates O2• - through type I photodynamic reactions, leading to lysosomal/mitochondrial damage, double-strand DNA breaks and apoptosis, with potential phototoxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
