12

Lifitegrast

12 Publications Verification

Cat. No.: HY-19344

CAS No.: 1025967-78-5

Synonyms: SAR 1118; SHP-606

Target:

Integrin

Research Areas:

Inflammation/Immunology

Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease ^[1].

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12

Lifitegrast sodium

12 Publications Verification

Cat. No.: HY-19344A

CAS No.: 1119276-80-0

Synonyms: SAR 1118 sodium; SHP-606 sodium

Target:

Integrin

Research Areas:

Inflammation/Immunology

Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease ^[1].

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5

BIRT 377

5 Cited Publications

Cat. No.: HY-110117

CAS No.: 213211-10-0

Purity: 99.82%

Target:

Integrin Interleukin Related

Research Areas:

Inflammation/Immunology

BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders ^[1].

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1

JAML/AMICA Protein, Mouse (HEK293, Fc)

1 Cited Publications

Cat. No.: HY-P76464

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: JAML; Adhesion Molecule, Interacts With CXADR antigen 1; Prev. AMICA1; Dendritic-Cell Specific Protein CREA7-4; Junctional Adhesion Molecule-Like; Dendritic Cell-Specific Protein CREA7-1; Gm638; Adhesion Molecule AMICA; AMICA; CREA7-1; Adhesion Molecule I

Species:

Mouse

Source:

HEK293

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1

Serpin B4 Protein, Human (sf9, His)

1 Cited Publications

Cat. No.: HY-P77198

Purity: ≥ 85%, as determined by reducing SDS-PAGE.

Synonyms: SERPINB4; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 4; Prev. SCCA2; Serpin B4; Squamous Cell Carcinoma antigen 2; Protease Inhibitor (Leucine-Serpin); SCCA-2; Squamous Cell Carcinoma antigen 1; PI11; SCCA2/SCCA1 Fusion Protein; LEUPIN; Leupi

Species:

Human

Source:

Sf9 insect cells

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HUHS015

Cat. No.: HY-100199

CAS No.: 1453097-13-6

Purity: 99.32%

Target:

PSMA

Research Areas:

Cancer

HUHS015 is a potent prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with an IC₅₀ of 0.67μM for PCA-1 ^[1].

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BMS-587101

Cat. No.: HY-120628

CAS No.: 509083-77-6

Purity: 99.39%

Target:

Integrin

Research Areas:

Inflammation/Immunology

BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research ^[1] .

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RWJ 50271

Cat. No.: HY-110086

CAS No.: 162112-37-0

Purity: 99.25%

Target:

Integrin

Research Areas:

Inflammation/Immunology

RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC₅₀ of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion ^[1].

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Nucleoprotein (396-404)

Cat. No.: HY-P1571

CAS No.: 158475-79-7

Synonyms: NP 396

Target:

Arenavirus

Research Areas:

Inflammation/Immunology

Nucleoprotein (396-404) is the 396 to 404 fragment of lymphocytic choriomeningitis virus (LCMV). Nucleoprotein (396-404) is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen .

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Atuzabrutinib

Cat. No.: HY-132808

CAS No.: 1581714-49-9

Purity: 98.01%

Synonyms: SAR 444727; PRN473

Target:

Btk

Research Areas:

Inflammation/Immunology

Atuzabrutinib (SAR 444727) is a potent, selective reversible inhibitor of Btk (Bruton's tyrosine kinase) inhibitor. Atuzabrutinib inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling ^[1].

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