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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
asexual replication
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "asexual replication" in MCE Product Catalog:
Cat. No.: HY-182309
CAS No.: 1237645-43-0
Target:
Research Areas:
SC83288 is a Plasmodium falciparum PfDNMT2 inhibitor with an IC50 of 7 μM. SC83288 disrupts the epigenetic regulation of malaria parasites, blocks DNA replication and nuclear division, arrests the development of the asexual blood stage, induces the formation of pyknotic morphology in malaria parasites, and does not affect cytokinesis after nuclear division or parasite egress. SC83288 is applicable to malaria-related research .
Cat. No.: HY-187123
CAS No.: 1396858-56-2
DDD01035881 is a Plasmodium falciparum Pfs16 inhibitor, with an EC50 of 130 nM for exflagellation of male gametes of Plasmodium falciparum NF54 gametocytes. DDD01035881 stabilizes mature activated male gametocyte Pfs16, mimics the Pfs16-deficient phenotype, blocks the early formation process of male gametes before DNA replication, inhibits exflagellation, and exhibits male-specific activity with no activity against female gametes or asexual malaria parasite stages. DDD01035881 can be used in malaria-related research .
Cat. No.: HY-187550
CAS No.: 1771650-41-9
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Research Areas:
BRD7929 is an orally active phenylalanyl-tRNA synthetase (PheRS) inhibitor and parasiticide, with an IC50 value of 0.023 μM against Plasmodium falciparum PheRS. BRD7929 inhibits the aminoacylation activity of the target enzyme, blocking protein synthesis, DNA replication and parasite nuclear division. BRD7929 clears the asexual blood stage, liver stage and mature gametocyte stage of malaria parasite species, and prevents parasite transmission to mosquitoes. BRD7929 shows moderate cytotoxicity against mammalian cells and inhibits hERG ion channels. BRD7929 achieves cure of malaria in animal models. BRD7929 can be used in research related to cryptosporidiosis and malaria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
