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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
base hydrolysis
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "base hydrolysis" in MCE Product Catalog:
10
10 Cited Publications
Cat. No.: HY-B0689
CAS No.: 150378-17-9
Synonyms: MK-639 free base; L-735524 free base
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Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CL pro inhibitor .
Cat. No.: HY-P2661
CAS No.: 78832-65-2
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Hemicellulase is a hemicellulose-targeting hydrolase that breaks down the binding of glucose and polymers to water molecules present in plant fibers. Hemicellulase specifically degrades hemicellulose (such as xylan and mannan) in plant cell walls by hydrolyzing β-1,4-xylosidic bonds and ester bonds (such as acetyl and ferulic acid ester bonds). Hemicellulase relies on the synergistic action of the glycoside hydrolase (GH) and carbohydrate esterase (CE) families to achieve efficient hydrolysis through acid-base catalysis (such as Glu/Asp residues) and substrate binding pockets. Hemicellulase can be used in the food industry (such as improving bread texture)， biofuel production (lignocellulose pretreatment) and paper industry (biobleaching) .
Cat. No.: HY-N6675
CAS No.: 94238-00-3
Category:
Natural Products Neurological Disease Plants Crocus sativus L. Lridaceae Extract Disease Research Fields Cancer
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Cat. No.: HY-150251
CAS No.: 2497583-03-4
Synonyms: STAT3 degrader-2
SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) .
Synonyms: mPEG1000-SC; mPEG1000-Succinimidyl ester
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m-PEG1000-NHS ester (mPEG1000-SC; mPEG1000-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG1000‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG1000-NHS ester can be used in drug delivery-related research .
Cat. No.: HY-W391506
CAS No.: 9011-14-7
Synonyms: Poly(methyl methacrylate), beads; PMMA
Research Areas:
Poly (methyl methacrylate) (Poly(methyl methacrylate), beads; PMMA) is an amorphous glassy acrylic thermoplastic polymer belonging to the acrylate family, synthesized from methyl methacrylate monomers. Poly (methyl methacrylate) drives biochemical processes including free volume expansion induced by inelastic deformation, yield stress and strain softening regulated by physical aging, acid hydrolysis to polymethacrylic acid, multi-stage combustion, oxygen-dependent thermal decomposition, primary amine-mediated polypentanimide formation, and grafting/crosslinking-based copolymer and composite formation. Poly (methyl methacrylate) exhibits histocompatibility, low toxicity, low inflammatory potential, and fracture resistance; it can form functional blends and composites for biomedical and dental applications; it also allows performance-enhancing chemical and mechanical modifications. Poly (methyl methacrylate) is applicable to studies related to cranial repair .
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins. Z-Val-Val-Arg-AMC exhibits preference for Cathepsin S. Z-Val-Val-Arg-AMC undergoes hydrolysis catalyzed by cathepsin to release the AMC fluorophore, thereby enabling fluorescence-based quantitative assessment of the target enzyme activity .
Synonyms: mPEG350-SC; mPEG350-Succinimidyl ester
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m-PEG350-NHS ester (mPEG350-SC; mPEG350-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG350‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG350-NHS ester can be used in drug delivery-related research .
Cat. No.: HY-D1221
CAS No.: 204697-37-0
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6-Fluorescein phosphoramidite is a fluorescein-based phosphoramidite reagent and fluorescent labeling reagent used for oligonucleotide probe synthesis. 6-Fluorescein phosphoramidite serves as a fluorescent label on gene-specific hydrolysis probes .
Cat. No.: HY-W012802
CAS No.: 1193-62-0
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Methyl 1H-pyrrole-2-carboxylate is a pyrrole-based synthetic building block that undergoes hydrolysis, cyclization, and other reactions. Methyl 1H-pyrrole-2-carboxylate serves as an intermediate for organic synthesis-related research .
Cat. No.: HY-155909
CAS No.: 92451-01-9
Synonyms: mPEG3400-SC; mPEG3400-Succinimidyl ester
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m-PEG3400-NHS ester (mPEG3400-SC; mPEG3400-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG3400‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG3400-NHS ester can be used in drug delivery-related research .
Cat. No.: HY-E70217
CAS No.: 59088-21-0
Synonyms: Heat-sensitive UDG
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Uracil DNA Glycosylase (UDG/UNG), heat-sensitive (Heat-sensitive UDG) can catalyze the hydrolysis of the N-glycosidic bond between the uracil base and the sugar phosphate backbone in the DNA chain containing uracil, releasing free uracil. Uracil DNA Glycosylase (UDG/UNG), heat-sensitive eliminates the carryover contamination dUTP-incorporated amplification products .
Cat. No.: HY-155909B
CAS No.: 92451-01-9
Synonyms: mPEG550-SC; mPEG550-Succinimidyl ester
Research Areas:
m-PEG550-NHS ester (mPEG550-SC; mPEG550-Succinimidyl ester) is a polyethylene glycol (PEG)-based biocompatibility-enhancing modifier. m‑PEG550‑NHS ester enables PEGylation of molecules such as proteins, which reduces the immunogenicity and antigenicity of target molecules, decreases the tendency of protein aggregation, and protects proteins from hydrolysis. m-PEG550-NHS ester can be used in drug delivery-related research .
Cat. No.: HY-167885
CAS No.: 1450615-41-4
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Cat. No.: HY-164949
CAS No.: 2762182-61-4
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Ribociclib acetate is a degradation product of Ribociclib (HY-15777) under acid-base hydrolysis conditions. Ribociclib acetate has been predicted to be carcinogenic .
Cat. No.: HY-101630A
CAS No.: 120444-72-6
Synonyms: EGIS-3886 fumarate
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Deramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of 5-HT2C Receptor with an IC50 of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis .
Cat. No.: HY-164685
CAS No.: 324572-92-1
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T-0156 free base is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 free base specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 free base inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 free base enhances the nitric oxide (NO)/cGMP pathway .
Cat. No.: HY-B0689S1
Synonyms: MK-639 free base-13C4,15N; L-735524 free base-13C4,15N
Cat. No.: HY-D1687
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
