21 Results for "

blast cells

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "blast cells" in MCE Product Catalog:

18
L-Asparaginase
L-Asparaginase
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18 Publications Verification
Cat. No.: HY-P1923
CAS No.: 9015-68-3
Synonyms: L-​ASNase
Target:  

Apoptosis DNA/RNA Synthesis

Research Areas:  

Cancer

L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis .
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4
Kevetrin hydrochloride
Kevetrin hydrochloride
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4 Cited Publications
Cat. No.: HY-16271
CAS No.: 66592-89-0
Synonyms: 4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride
Target:  

MDM-2/p53 Apoptosis

Research Areas:  

Cancer

Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells .
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3
Tricyclazole
Tricyclazole
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3 Cited Publications
Cat. No.: HY-B0848
CAS No.: 41814-78-2
Target:  

Environmental Pollutants Bacterial

Research Areas:  

Infection Metabolic Disease

Tricyclazole is a pentaketone melanin biosynthesis inhibitor and a unique fungicide for controlling rice blast. Tricyclazole alters the structure and function of fungal cell walls, reduces fungal pathogenicity and penetration, and causes dose-dependent liver damage in animals .
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GSK321
GSK321
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1 Cited Publications
Cat. No.: HY-18948
CAS No.: 1816331-63-1
Target:  

Isocitrate Dehydrogenase (IDH)

Research Areas:  

Cancer

GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular α-Hydroxyglutaric acid (2-HG) (HY-113038B), abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers .
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1
KPT-185
KPT-185
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1 Cited Publications
Cat. No.: HY-15611
CAS No.: 1333151-73-7
Purity:  98.21%
Target:  

CRM1

Research Areas:  

Cancer

KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts .
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Pivekimab
Pivekimab
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Cat. No.: HY-P99234
CAS No.: 2234335-84-1
Synonyms: IMGN632 Antibody; G4723A
Target:  

Interleukin Related ADC Antibodies

Research Areas:  

Cancer

Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .
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Gemtuzumab
Gemtuzumab
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Cat. No.: HY-P99971
CAS No.: 2924764-21-4

Target:  

ADC Antibodies Transmembrane Glycoprotein

Research Areas:  

Cancer

Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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Ferumoxytol
Ferumoxytol
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Cat. No.: HY-108894
CAS No.: 722492-56-0
Purity:  95.00%
Target:  

Ferroptosis Reactive Oxygen Species (ROS)

Research Areas:  

Inflammation/Immunology Cancer

Ferumoxytol is an FDA-approved ultrasmall superparamagnetic iron oxide preparation and iron replacement agent that exerts selective activity against leukemia cells with low ferroportin expression. Ferumoxytol increases intracellular iron levels, induces reactive oxygen species (ROS) production via the Fenton reaction, and triggers oxidative stress and cell death. Ferumoxytol reduces disease burden in mouse models and patient-derived leukemia models. As an MRI contrast agent, Ferumoxytol enables imaging of vascular lesions, tumors and lymph nodes. Ferumoxytol can be used in research related to acute myeloid leukemia and blast-phase chronic myeloid leukemia .
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Feruloyl esterase
Feruloyl esterase
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Cat. No.: HY-E70115
CAS No.: 134712-49-5
Target:  

Fungal Bacterial

Research Areas:  

Infection

Feruloyl esterase is a subclass of carboxylesterases that hydrolyzes the ester linkages between hydroxycinnamic acids and arabinoxylan/pectin polysaccharides in plant cell walls. Feruloyl esterase can hydrolyze ethyl ferulate to release ferulic acid, disrupt plant cell wall structure, promote fiber swelling, and facilitate cellulase hydrolysis. Feruloyl esterase synergizes with xylanase by removing ferulic acid side chains, thereby promoting efficient hydrolysis of xylan into monomers. Feruloyl esterase acts as a virulence factor for Verticillium dahliae VdFAE and Magnaporthe oryzae Fae1, facilitating host infection and colonization. Feruloyl esterase promotes the degradation of cotton GhDFR through binding to its NADPH domain, thereby inhibiting flavonoid-mediated innate immunity and inducing cell death in Nicotiana benthamiana. Feruloyl esterase can be used in studies related to verticillium wilt and rice blast .
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(S,R)-GSK321
(S,R)-GSK321
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Cat. No.: HY-128888B
CAS No.: 1816272-18-0
Purity:  98.62%
Target:  

Isocitrate Dehydrogenase (IDH)

Research Areas:  

Cancer

(S,R)-GSK321 is the (S,R)-enantiomer of GSK321 (HY-18948). GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers .
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MEN1112
MEN1112
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Cat. No.: HY-P991665
Synonyms: OBT357NF; OBT357

Target:  

Transmembrane Glycoprotein

Research Areas:  

Cancer

MEN1112 (OBT357NF; OBT357) is a defucosylated humanized monoclonal antibody targeting Bst1/CD157, with an EC50 of 0.4 nM. MEN1112 binds to Bst1/CD157 on acute myeloid leukemia cells, triggers slow antigen internalization, induces antibody-dependent cell-mediated cytotoxicity, and mediates the lysis of acute myeloid leukemia cells and blasts. MEN1112 is applicable for research related to acute myeloid leukemia .
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Bexatamig
Bexatamig
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Cat. No.: HY-P990905
CAS No.: 2871775-98-1
Synonyms: SAR-443579

Target:  

Interleukin Related

Research Areas:  

Cancer

Bexatamig (SAR-443579) is a trifunctional natural killer cell engager targeting IL-3R α/CD123, NKp46/NCR1/CD335 and Fc gamma RIIIA/CD16a. Bexatamig forms a cytolytic synapse between natural killer cells and CD123-positive tumor cells. By activating natural killer cells to induce tumor cell death, Bexatamig effectively reduces the burden of CD123-positive acute myeloid leukemia (AML) blasts. Bexatamig has been granted FDA Fast Track designation, and is primarily investigated for relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, and high-risk myelodysplastic syndromes .
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Verlamelin B
Verlamelin B
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Cat. No.: HY-P11343
CAS No.: 1619237-95-4
Category:  

Natural Products Microorganisms

Target:  

Fungal

Verlamelin B (Compound 147) is effective against plant pathogenic fungal and is a derivative of Verlamelin (HY-N14856).Verlamelin B exhibits potent plant protective activity in vivo, particularly against rice blast and barley powdery mildew. Verlamelin B causes morphological changes in fungal cells, such as swelling or expansion. Verlamelin B exhibits weaker antifungal activity in vitro against plant pathogens such as rice blast, Dipolaris zeae, and Botrytis cinerea. Verlamelin B is useful for research on antifungal activities against plant pathogens .
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AT-1413
AT-1413
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Cat. No.: HY-P991425
Target:  

Transmembrane Glycoprotein

Research Areas:  

Cardiovascular Disease Cancer

AT-1413 is a monoclonal antibody targeting CD43s that recognizes a unique sialylated CD43 epitope spanning amino acid residues 133-165. AT1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) in AML cells, with EC50 values of 1.1 nM and 12.4 nM, respectively. AT-1413 binds to a variety of cancer cells, shows weak binding to non-malignant myeloid cells and endothelial cells, and does not bind to healthy lymphoid cells or normal non-hematopoietic cells. AT1413 clears CD43s-expressing leukemic blasts in vivo without affecting non-malignant myeloid cells. AT-1413 can be used in research related to acute myeloid leukemia, myelodysplastic syndrome, melanoma, and breast cancer .
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MGTA-117 Antibody
MGTA-117 Antibody
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Cat. No.: HY-P991294

Target:  

ADC Antibodies

Research Areas:  

Cancer

MGTA-117 is a humanized monoclonal antibody targeting CD117. MGTA-117 can be used for synthesis of antibody-drug conjugate (ADC), utilizing an amanitin payload. MGTA-117 has potent anti-tumor activity and increases survival in three acute myeloid leukemia (AML) xenograft hNSG mice models (Kasumi-1, AML PDX 1 and AML PDX 2). MGTA-117 enables hematopoietic stem cell transplantation (HSCT) preprocessing in AML, myelodysplasia with excess blasts (MDS-EB) and gene therapy .
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ME 2303
ME 2303
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Cat. No.: HY-106326
CAS No.: 116521-53-0
Synonyms: FAD 104
Target:  

Others

Research Areas:  

Cancer

ME 2303 (FAD 104) is a fluoro-pyranosyl adriamycin analogue with anti-tumor potential. ME 2303 can inhibit the proliferation of acute undifferentiated myeloblastic leukemia (AML) blast cells in a dose-dependent manner. ME 2303 can be used for the study of acute undifferentiated myeloblastic leukemia (AML) .
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Antifungal agent 180
Antifungal agent 180
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Cat. No.: HY-189372
CAS No.: 3117572-66-1
Target:  

Drug Derivative Fungal

Research Areas:  

Infection

Antifungal agent 180 is a pyrazole-oxadiazole-linked 1,2,4-triazole derivative and a broad-spectrum antifungal agent. Antifungal agent 180 disrupts fungal cellular homeostasis through multiple pathways, damaging the integrity of fungal hyphal cell membranes, increasing membrane permeability, and causing leakage of intracellular nucleic acids and proteins; it induces hyphal shrinkage, collapse, and organelle disintegration; and it causes widespread dysregulation of sterol/lipid metabolism, carbohydrate utilization, mitochondrial respiration, and stress response pathways at both the transcriptomic and proteomic levels. Antifungal agent 180 exhibits protective and curative efficacy against rice blast in vivo. Antifungal agent 180 can be used in research on rice blast and gray mold .
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Medicagenic acid 3-O-glucoside
Medicagenic acid 3-O-glucoside
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Cat. No.: HY-N17503
CAS No.: 49792-23-6
Category:  

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