5 Results for "

bloodstream-form

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "bloodstream-form" in MCE Product Catalog:

5
L-Anserine nitrate
L-Anserine nitrate
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5 Cited Publications
Cat. No.: HY-W011393
CAS No.: 10030-52-1
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Parasite

L-Anserine nitrate is a naturally occurring histidine-containing dipeptide that is found in vertebrate skeletal muscle and animal tissues. L-Anserine nitrate serves as a growth-promoting supplement in serum-free HMI-244 medium for bloodstream forms of Trypanosoma brucei and Trypanosoma evansi. L-Anserine nitrate supports the continuous in vitro proliferation of these parasites, and the proliferated parasites retain their morphological characteristics and infectivity to mice. L-Anserine nitrate can be used in studies of African trypanosomiasis .
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Venturicidin A
Venturicidin A
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Cat. No.: HY-N125722
CAS No.: 33538-71-5
Synonyms: Aabomycin A1
Category:  

Infection Macrolide Antibiotics Antibiotics Microorganism Disease Research Antibacterial Disease Research Fields

Target:  

Endogenous Metabolite ATP Synthase Parasite Fungal Reactive Oxygen Species (ROS)

Venturicidin A (Aabomycin A1) is a natural product derived from Streptomyces, possessing antifungal, anti-Trypanosoma brucei, anti-Leishmania donovani, and ATP synthase inhibitory activities. Venturicidin A acts as an antibiotic adjuvant, promoting the uptake of aminoglycoside antibiotics and enhancing bactericidal efficacy. Venturicidin A inhibits ATP synthesis by blocking proton translocation through the FO subunit. In bloodstream-form Trypanosoma brucei, Venturicidin A causes collapse of the mitochondrial membrane potential; in fungi, it disrupts cell membrane integrity, induces leakage of cytoplasmic contents, elevates ROS levels, and downregulates the expression of fungal pathogenicity-related genes. Venturicidin A exhibits antifungal activity against Botrytis cinerea. Venturicidin A is used in research on bacterial infections, trypanosome/leishmania infections, and gray mold disease .
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PEX5-PEX14 PPI-IN-1
PEX5-PEX14 PPI-IN-1
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Cat. No.: HY-155530
CAS No.: 3052256-26-2
Target:  

Bacterial

Research Areas:  

Infection

PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 PPI inhibitor. PEX5-PEX14 PPI-IN-1 disrupts the PEX5-TbPEX14 PPI with a Ki of 53 μM. PEX5-PEX14 PPI-IN-1 inhibits the bloodstream form of T. b. brucei (EC50: 5 μM) .
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Antitrypanosomal agent 12
Antitrypanosomal agent 12
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Cat. No.: HY-149985
Target:  

Parasite

Research Areas:  

Infection

Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12 shows antitrypanosomal activity with 50% growth inhibition (GI50) values of 0.22 μM. Antitrypanosomal agent 12 induces faster cell swelling in bloodstream-form trypanosomes than Salinomycin (HY-15597) .
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Melarsen oxide
Melarsen oxide
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Cat. No.: HY-133983
CAS No.: 21840-08-4
Target:  

Glutathione Reductase (GR) Parasite

Research Areas:  

Infection

Melarsen oxide is a blood-brain barrier-permeable, competitive antimalarial agent and Glutathione reductase inhibitor with a Ki of 23.7 μM. Melarsen oxide induces rapid lysis of bloodstream-form Trypanosoma brucei cells by disrupting the plasma membrane. Melarsen oxide exhibits trypanocidal activity against Trypanosoma brucei rhodesiense. Melarsen oxide is applicable to research related to filariasis and African trypanosomiasis .
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