Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
cell junction proteins
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "cell junction proteins" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Target:
Liposome Endogenous Metabolite ACSL Family Amino acid Transporter Ferroptosis Glutathione Peroxidase
Research Areas:
DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease .
13
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
7
7 Cited Publications
Cat. No.: HY-W013636C
CAS No.: 997-43-3
Synonyms: Alpha-Ketoglutaric acid potassium
1
1
Category:
Leguminosae/Fabaceae Extract Natural Products Plant Other Diseases Arachis hypogaea L. Extract Disease Research Fields
Target:
Cat. No.: HY-P99413
CAS No.: 1650599-68-0
Synonyms: ASP1650
Cat. No.: HY-W015777
CAS No.: 105-13-5
Synonyms: P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol
Cat. No.: HY-170522
CAS No.: 2924181-80-4
Synonyms: ISM012-042
Target:
Research Areas:
Garutadustat (ISM012-042) is an orally active, selective inhibitor of PHD1 and PHD2, with IC50 values of 1.9 nM and 2.5 nM, respectively. Garutadustat stabilizes HIF1α protein in intestinal epithelial cells, thereby activating gene transcription programs associated with mucus production, tight junction formation, anti-inflammatory mediator generation and wound healing, which fundamentally promotes mucosal barrier repair and regulates intestinal immunity. Garutadustat can be used for the research of inflammatory bowel disease .
Cat. No.: HY-N4031
CAS No.: 82375-29-9
Cat. No.: HY-P10886
CAS No.: 1465809-36-2
Target:
Research Areas:
Cat. No.: HY-P5694
Human α-defensin 5 is an orally active antimicrobial peptide with diverse biological activities including antibacterial, antiviral, and antiparasitic effects. Human α-defensin 5 kills UPEC, inhibits bacterial biofilm formation, and disrupts bacterial outer membrane integrity. Human α-defensin 5 is hijacked by Shigella flexneri, enhancing Shigella adhesion, aggregation, and invasion of host epithelial cells, and aggravating histopathological damage in corneal and colonic tissues as well as fever. Human α-defensin 5 inhibits LPS-induced pro-inflammatory cytokine production and NF-κB signaling pathway activation, upregulates the tight junction proteins ZO-1 and occludin, and maintains intestinal epithelial barrier integrity. Human α-defensin 5 inhibits various non-enveloped viruses and exhibits killing activity against Toxoplasma gondii tachyzoites. Human α-defensin 5 reduces UPEC bacterial load in the bladder and urine and alleviates inflammatory damage in a rat catheter-associated urinary tract infection model. Human α-defensin 5 can be used in research related to bacterial infections, viral infections, parasitic infections, and inflammatory bowel disease .
Cat. No.: HY-N6799
CAS No.: 36519-25-2
Cat. No.: HY-15651A
CAS No.: 1240425-05-1
Synonyms: AZD9668 tosylate
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat tosylate (AZD9668 tosylate) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat tosylate reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat tosylate restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat tosylate prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat tosylate inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat tosylate can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
Cat. No.: HY-15651R
CAS No.: 848141-11-7
Synonyms: AZD9668 (Standard)
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat (Standard) (AZD9668 (Standard)) is the analytical standard of Alvelestat (HY-15651). This product is intended for research and analytical applications. Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
Cat. No.: HY-174735
Human CDH5 mRNA encodes the human cadherin 5 (CDH5) protein, a classical cadherin of the cadherin superfamily. CDH5 functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner. It plays a role in endothelial adherens junction assembly and maintenance.
Cat. No.: HY-N6799R
CAS No.: 36519-25-2
Category:
Cat. No.: HY-W015777R
CAS No.: 105-13-5
Synonyms: P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)
Cat. No.: HY-15651S
Synonyms: AZD9668-13C,d3
Cat. No.: HY-N7764
CAS No.: 79786-08-6
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
