99

99 Publications Verification

Synonyms: Niacinamide; Nicotinic acid amide

Category:

Alkaloids Human Gut Microbiota Metabolites Microorganisms Neurological Disease Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer

Target:

Environmental Pollutants Endogenous Metabolite Sirtuin HBV Organoid

Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC₅₀: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .

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21

c-di-AMP disodium

21 Cited Publications

Cat. No.: HY-12326A

CAS No.: 2734909-87-4

Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

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21

c-di-AMP diammonium

21 Cited Publications

Cat. No.: HY-12326B

Purity: 99.36%

Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Bacterial Endogenous Metabolite

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

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1

Nicotinamide (Standard)

1 Cited Publications

Cat. No.: HY-B0150R

CAS No.: 98-92-0

Synonyms: Niacinamide(Standard); Nicotinic acid amide (Standard)

Target:

Reference Standards Endogenous Metabolite Sirtuin

Research Areas:

Cancer

Nicotinamide (Standard) is the analytical standard of Nicotinamide. This product is intended for research and analytical applications. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC₅₀: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD₊, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .

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c-di-AMP

Cat. No.: HY-12326

CAS No.: 54447-84-6

Synonyms: Cyclic diadenylate; Cyclic-di-AMP

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

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Lintuzumab

Cat. No.: HY-P9983

CAS No.: 166089-32-3

Synonyms: SGN-33; HuM-195; GLK-33 Antibody

Lintuzumab (HUM-195) is an anti-CD33 humanized monoclonal antibody. Lintuzumab reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells. Lintuzumab promotes tumor cell killing through antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) activities against MDR and MDR+ AML cell lines and primary AML patient samples. Lintuzumab enhances survival and reduces tumor burden in mice .

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Nesfrotamig

Cat. No.: HY-P991149

CAS No.: 2966936-23-0

Synonyms: YH32367; ABL105

Nesfrotamig (YH32367; ABL105) is a bispecific activator targeting HER2 and 4-1BB. The K_d values of Nesfrotamig for human HER2 and human 4-1BB are 0.48 nM and 3.36 nM, respectively. By blocking tumor cell growth signals, activating HER2-dependent local 4-1BB in tumors to maintain T cell survival, and inducing NK cell-mediated antibody-dependent cellular cytotoxicity, Nesfrotamig enhances the cytotoxicity and tumor infiltration ability of immune cells. Nesfrotamig promotes the generation of tumor-specific memory T cells, drives T cell-mediated tumor lysis, exhibits significant anti-tumor efficacy against both HER2-positive and HER2-low-expressing tumors, and shows synergistic activity when combined with anti-PD-1 antibodies. In cynomolgus monkey studies, Nesfrotamig demonstrates good safety and is suitable for research related to HER2-positive and HER2-low-expressing tumors .

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