![Benzo[b]thiophene-3-carbaldehyde](https://file.medchemexpress.com/product_pic/hy-w002251.gif "Click to View Benzo[b]thiophene-3-carbaldehyde Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
chalcone derivatives
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "chalcone derivatives" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-W082785A
CAS No.: 24533-47-9
Target:
TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS)
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .
1
1 Cited Publications
Synonyms: (E/Z)-Benzylideneacetophenone
Cat. No.: HY-W002251
CAS No.: 5381-20-4
Cat. No.: HY-N7516
CAS No.: 151135-64-7
Synonyms: PS-IX; AM114
Target:
Research Areas:
Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53 +/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity .
Cat. No.: HY-W002179
CAS No.: 15164-44-0
Cat. No.: HY-N10917
CAS No.: 688360-06-7
Target:
Target:
Research Areas:
Antioxidant agent-1 is a new chalcone derivative as a potential antioxidant agent.
Target:
Research Areas:
Anti-inflammatory agent 32 is a chalcone derivative with anti-inflammatory activity. Anti-inflammatory agent 32 can be used for the research of inflammatory bowel disease .
Cat. No.: HY-W012349
CAS No.: 1214-47-7
2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells . 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp .
Cat. No.: HY-148568
CAS No.: 2883408-32-8
Research Areas:
TMV-IN-2, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-2 has antiviral activity against TMV with an EC50 value of 89.9 μg/mL. TMV-IN-2 can be used for the research of infection, inflammation and tumor .
Cat. No.: HY-W325160
CAS No.: 956-04-7
Research Areas:
4-Chlorochalcone (Compound 3) is a monoamine oxidase inhibitor (hMAO-B: IC50 = 0.082 μM, hMAO-A: IC50 = 9.95 μM). 4-Chlorochalcone also exhibits inhibitory activity against cholinesterase (AChE: IC50 = 2.79 μM). 4-Chlorochalcone is a chalcone derivative .
Cat. No.: HY-121054R
CAS No.: 94-41-7
Synonyms: (E/Z)-Benzylideneacetophenone (Standard)
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Chalcones Glycyrrhiza uralensis Fisch. Extract Endogenous metabolite
Target:
Cat. No.: HY-W300403A
CAS No.: 68461-38-1
Target:
Research Areas:
Cinfenoac disodium is a chalcone derivative with anti-inflammatory activity and can be used in the study of allergic diseases.
Cat. No.: HY-145858
CAS No.: 2756846-09-8
Target:
Research Areas:
Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD .
Cat. No.: HY-137831
CAS No.: 562823-84-1
TLBC, a boronic-chalcone derivative, shows a dose-dependent inhibition with IC50 values of 5.5-25.5 μM in various glioma cell lines. TLBC induces apoptosis independent of changes to the tumor suppressor p53 .
Cat. No.: HY-N7557
CAS No.: 79140-20-8
Target:
Research Areas:
(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities .
Cat. No.: HY-164361
CAS No.: 42220-80-4
Target:
Research Areas:
α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells .
Cat. No.: HY-148569
CAS No.: 2883408-35-1
Research Areas:
TMV-IN-3, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-3 has antiviral activity against TMV with an EC50 value of 120.3 μg/mL. TMV-IN-3 can be used for the research of infection, inflammation and tumor .
Cat. No.: HY-124345
CAS No.: 1309371-03-6
Target:
Research Areas:
2-Trifluoromethyl-2'-methoxychalcone is a chalcone derivative. 2-Trifluoromethyl-2'-methoxychalcone is a potent Nrf2 activator. 2-Trifluoromethyl-2'-methoxychalcone can be used for oxidative stress and inflammation related diseases research .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
