4 Results for "

chronic itch

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "chronic itch" in MCE Product Catalog:

Cat. No.: HY-P3445
CAS No.: 2269511-95-5
Synonyms: HSK21542
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

Anrikefon is a peripherally restricted kappa opioid receptor (KOR) agonist, with an IC50 of 0.54 nM, an EC50 of 2.41 pM, and a Ka of 0.068 nM against human KOR, and it exhibits high selectivity over μ and δ opioid receptors. Anrikefon exerts analgesic effects by inhibiting behaviors associated with inflammatory, postoperative and neuropathic pain, and also exerts antipruritic effects by reducing itch-related behaviors. Anrikefon can be used in research on pain, pruritus, and pruritus associated with chronic kidney disease .
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Cat. No.: HY-147051
CAS No.: 2492595-24-9
Purity:  99.94%
Synonyms: MRGPRX4 modulator-2
MRGPRX4 modulator-2 (compound 1-55) is a potent MRGPR X4 modulator, possessing antagonist activity against MRGPR X4 with an IC50 < 100 nM. MRGPRX4 modulator-2 can be used for researching autoimmune diseases such as psoriasis, multiple sclerosis, Steven Johnson’s Syndrome, and other chronic itch conditions .
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Cat. No.: HY-175672
CAS No.: 3137192-95-8
MRGPRX4 modulator-3 (Compound 1C) is a negative allosteric MAS-related G-protein-coupled receptor X4 (MRGPRX4) modulator. MRGPRX4 modulator-3 significantly attenuates Nateglinide (HY-B0422) (orthosteric agonist)-induced responses with an IC50 of 337 nM. MRGPRX4 modulator-3 can be used for chronic itch (especially cholestatic itch) and pain research .
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Cat. No.: HY-N12040
CAS No.: 569-02-8
Synonyms: Iso-γ-fagarine
γ-Isofagarine (Iso-γ-fagarine) is an alkaloid that can be isolated from the root bark of Dictamnus angustifolius. Dictamnus angustifolius has been used in the research of rheumatism, bleeding, itching, jaundice, chronic hepatitis, skin diseases, etc .
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