38

38 Publications Verification

Synonyms: β-Nicotinamide mononucleotide; β-NM; NMN

Category:

Neurological Disease Other disease Anti-aging Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Disease Research Fields Cancer

Target:

Endogenous Metabolite

Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD ⁺ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .

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32

TRAM-34

32 Cited Publications

Cat. No.: HY-13519

CAS No.: 289905-88-0

Purity: 99.73%

Target:

Potassium Channel

Research Areas:

Neurological Disease

TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K ⁺ channel (IKCa1) (K_d=20 nM).

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26

2′,7′-Dichlorofluorescein diacetate

26 Cited Publications

Cat. No.: HY-126793

CAS No.: 2044-85-1

Purity: 98.95%

Synonyms: DCFH2-DA

2′,7′-Dichlorofluorescein diacetate (DCFH2-DA) is a cell-permeable fluorescent probe. 2′,7′-Dichlorofluorescein diacetate can be used to detect the generation of reactive oxygen intermediates and for assessing the overall oxidative stress in toxicological phenomenon .

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24

Protoporphyrin IX

24 Cited Publications

Cat. No.: HY-B1247

CAS No.: 553-12-8

Synonyms: PPIX

Category:

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma .

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24

Protoporphyrin IX disodium

24 Cited Publications

Cat. No.: HY-B1247A

CAS No.: 50865-01-5

Synonyms: PPIX disodium

Target:

Endogenous Metabolite

Research Areas:

Cancer

Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma .

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20

Pyruvic acid

20 Cited Publications

Cat. No.: HY-Y0781

CAS No.: 127-17-3

Synonyms: Acetylformic acid

Category:

Endocrine diseases Endogenous metabolite Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder

Target:

Environmental Pollutants Endogenous Metabolite

Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.

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20

SAH

20 Cited Publications

Cat. No.: HY-19528

CAS No.: 979-92-0

Synonyms: SAH (S-Adenosylhomocysteine)

Category:

Human Gut Microbiota Metabolites Microorganisms Disease markers Metabolic Disease Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

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13

IMT1

13 Cited Publications

Cat. No.: HY-134539

CAS No.: 2304621-31-4

Purity: 98.13%

Target:

Oxidative Phosphorylation Mitochondrial Metabolism DNA/RNA Synthesis

Research Areas:

Metabolic Disease Cancer

IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases .

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12

Succinic acid

12 Cited Publications

Cat. No.: HY-N0420

CAS No.: 110-15-6

Synonyms: Wormwood acid

Category:

Neurological Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Food Research

Target:

Environmental Pollutants Endogenous Metabolite

Succinic acid is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid is an important platform chemical. Succinic acid can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

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12

Disodium succinate

12 Cited Publications

Cat. No.: HY-W015410

CAS No.: 150-90-3

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields .

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12

6PPD-Q

12 Cited Publications

Cat. No.: HY-153169

CAS No.: 2754428-18-5

Purity: 99.30%

Synonyms: 6PPD-Quinone

Category:

Alkaloids Quinones Other Alkaloids Other Diseases Benzene Quinones Endogenous metabolite Disease Research Fields

Target:

α-synuclein Environmental Pollutants

6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders .

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