29 Results for "

coculture

" in MedChemExpress (MCE) Product Catalog:
Products (29)

29 Results for "coculture" in MCE Product Catalog:

2
Tinurilimab
Tinurilimab
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2 Cited Publications
Cat. No.: HY-P99051
CAS No.: 2226224-30-0
Synonyms: BAY 1834942

Target:  

Transmembrane Glycoprotein

Research Areas:  

Inflammation/Immunology Cancer

Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system .
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PD-L1-IN-1
PD-L1-IN-1
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1 Cited Publications
Cat. No.: HY-139781
CAS No.: 2767424-13-3
Purity:  98.01%
Target:  

PD-1/PD-L1 Apoptosis

Research Areas:  

Cancer

PD-L1-IN-1 (Compound 10) is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly exhibits low cytotoxicity in healthy cells .
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Calotatug ginistinag
Calotatug ginistinag
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Cat. No.: HY-164919
CAS No.: 2847102-44-5
Synonyms: XMT-2056
Target:  

Antibody-Drug Conjugates (ADCs) EGFR STING IFNAR TNF Receptor Interleukin Related CXCR

Research Areas:  

Inflammation/Immunology Cancer

Calotatug ginistinag (XMT-2056) is an antibody-drug conjugate (ADC) targeting HER2, linked to a payload composed of XMT-1519 conjugate-1 (HY-148067) and STING agonist-20 (HY-148068). Calotatug ginistinag activates the STING signaling pathway in tumor cells and tumor-resident immune cells, induces the production of type I interferons and cytokines (CXCL10, IFN-β, IL-6, TNF-α, triggers innate anti-tumor immune responses, and exerts a bystander effect. Calotatug ginistinag exhibits efficacy against HER2-expressing cancer cells in co-culture with PBMCs. Calotatug ginistinag induces tumor regression and reduces systemic inflammation in various tumor models. Combination treatment with Calotatug ginistinag, Trastuzumab (HY-P9907) and T-DXd (HY-138298) yields benefits. Calotatug ginistinag can be used in studies related to HER2-expressing solid tumors such as breast cancer, gastric cancer and ovarian cancer .
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PROTAC PD-1/PD-L1 degrader-1
PROTAC PD-1/PD-L1 degrader-1
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Cat. No.: HY-131183
CAS No.: 2447066-37-5
Purity:  99.52%
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Inflammation/Immunology

PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner .
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MeOSuc-AAPV-CMK
MeOSuc-AAPV-CMK
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Cat. No.: HY-136888
CAS No.: 65144-34-5
Purity:  99.73%
Synonyms: Elastase Inhibitor III
Target:  

Elastase Cathepsin Interleukin Related

Research Areas:  

Inflammation/Immunology

MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an elastase inhibitor that simultaneously inhibits Cathepsin G and Proteinase 3. MeOSuc-AAPV-CMK blocks the shedding of FcgRIIIb on the surface of human neutrophils. MeOSuc-AAPV-CMK reverses the elastase-mediated reduction in proinflammatory cytokine production by immune cells, partially restores IL-1β levels in immune cell co-culture systems, and prevents elastase-mediated adiponectin cleavage .
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Flagellin from S. typhimurium
Flagellin from S. typhimurium
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Cat. No.: HY-NP134
Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting IL-10 production, and increasing the IFN-γ/IL-10 ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases .
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GJ19
GJ19
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Cat. No.: HY-174830
CAS No.: 3099808-68-8
Target:  

PD-1/PD-L1

Research Areas:  

Cancer

GJ19 is a PD-L1 inhibitor with an IC50 of 32.06 nM. GJ19 can effectively bind to human/murine PD-L1 protein with Kd values of 171 and 290 nM, respectively. GJ19 concentration-dependently promotes HepG2 cell mortality in a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells. GJ19 effectively suppresses tumor growth in a B16-F10 melanoma mouse model. GJ19 can be used for the study of tumor immunotherapy .
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LD2-3
LD2-3
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Cat. No.: HY-178238
CAS No.: 3040077-52-6
Target:  

ADC Payloads Topoisomerase

Research Areas:  

Cancer

LD2-3 is a cytotoxic compound derived from Exatecan (HY-13631), designed to be conjugated with anti-FGFR2b or anti-CEA antibodies to form intact antibody-drug conjugate (ADC) molecules. LD2-3 exhibits a remarkable bystander killing effect: it not only effectively kills FGFR2b-positive tumor cells, but also eliminates surrounding FGFR2b-negative cells in co-culture and mixed tumor xenograft models, thereby inducing complete tumor regression. LD2-3 can be used for anti-tumor research in relevant fields such as gastric cancer and lung cancer .
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EBET-1055
EBET-1055
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Cat. No.: HY-161346
Target:  

PROTACs Epigenetic Reader Domain

Research Areas:  

Cancer

EBET-1055 is a bromodomain and extra-terminal (BET) PROTAC degrader. EBET-1055 effectively inhibits the growth of pancreatic ductal adenocarcinoma (PDAC). EBET-1055 also simultaneously modulates cancer-associated fibroblast (CAF) activity, upregulating all reporter gene activities in organoid co-cultures .
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(Rac)-EBET-1055
(Rac)-EBET-1055
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Cat. No.: HY-161346A
CAS No.: 3031540-65-2
Target:  

PROTACs Epigenetic Reader Domain

Research Areas:  

Cancer

(Rac)-EBET-1055 is the racemate of EBET-1055 (HY-161346). EBET-1055 is a bromodomain and extra-terminal (BET) PROTAC degrader. EBET-1055 effectively inhibits the growth of pancreatic ductal adenocarcinoma (PDAC). EBET-1055 also simultaneously modulates cancer-associated fibroblast (CAF) activity, upregulating all reporter gene activities in organoid co-cultures .
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CD28-IN-1
CD28-IN-1
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Cat. No.: HY-175780
CAS No.: 1465291-19-3
Target:  

CD28 IFNAR TNF Receptor Interleukin Related

Research Areas:  

Cancer

CD28-IN-1 (Compound 19MS-5) is a CD28 inhibitor with a KD of 12.48  μM. CD28-IN-1 has a superior binding capacity to CD28 and potently inhibits CD28-B7 interactions. CD28-IN-1 inhibits CD28-driven immune activation and suppresses cytokine (IFN-γ, IL-2 and TNF-α) production in primary human T cells co-cultured with tumor spheroids and human epithelial tissues. CD28-IN-1 can be used for tumor immunity research .
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o,p'-DDE
o,p'-DDE
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Cat. No.: HY-121779
CAS No.: 3424-82-6
Synonyms: 2,4'-DDE; 2,4-Dichlorodiphenyldichloroethylene; 2,4'-DDE; o,p'-Dichlorodiphenyldichloroethylene
Target:  

Insecticide

Research Areas:  

Endocrinology

o,p'-DDE (2,4-Dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass, and in sediments from DDT manufacturing plants around the Huntsville Spring Branch-Indian Creek tributary system, where it is considered a persistent organic pollutant (POP). o,p'-DDE inhibits estrogen binding to the rainbow trout estrogen receptor (rtER) with an IC50 value of 3.2 μM. It induces concentration-dependent estradiol secretion in co-cultures of granulosa and theca cells isolated from porcine follicles. In ovo exposure to o,p'-DDE increases follicular degeneration and reduces testis size in Japanese medaka (O. latipes).
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(2E,4E)-Decadienoic acid
(2E,4E)-Decadienoic acid
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Cat. No.: HY-N10751
CAS No.: 30361-33-2
Category:  

Piperaceae Extract Ketones, Aldehydes, Acids Plants 500 - Internal Server Error | MedChemExpress

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