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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
colon tissue
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "colon tissue" in MCE Product Catalog:
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Zotiraciclib (TG02; SB1317) is an orally active JAK2/FLT3/CDK2 inhibitor with IC50 values of 13 nM, 73 nM and 56 nM , respectively. Zotiraciclib inhibits cancer cell proliferation, tumor growth and the activity of CYP2D6. Zotiraciclib exhibits high plasma protein binding rate, Caco-2 permeability and tissue distribution capacity, as well as metabolic stability in human and canine liver microsomes. Zotiraciclib achieves tumor growth inhibition in nude mouse models of colon cancer and lymphoma xenografts. Zotiraciclib can be used for research related to colon cancer, B-cell lymphoma, advanced leukemia, acute leukemia and multiple myeloma .
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1 Cited Publications
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(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-targeting PROTAC molecule. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine not only targets the ubiquitination and degradation of Smad3, but also elevates the protein level of HIF-α, thereby exerting multi-pathway anti-fibrotic and renoprotective effects. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can be used in a wide range of tumor studies including cancers with KRAS inhibitor resistance, covering pancreatic ductal adenocarcinoma, acute myeloid leukemia, and various soft tissue sarcomas (such as fibrosarcoma, liposarcoma, chondrosarcoma, etc.). (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can also be applied to research related to various solid tumors and hematological malignancies, involving multiple cancer types such as colon cancer, breast cancer, ovarian cancer, non-small cell lung cancer, glioblastoma, and melanoma .
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Curcumin-β-D-glucuronide is a major metabolite after oral intake of Curcumin in hepatic tissue and portal blood. Curcumin-β-D-glucuronide can be used for the research of colon cancer .
Cat. No.: HY-W324435
CAS No.: 885-62-1
Synonyms: Sodium 2,4-dinitrobenzenesulfonate; DNBS sodium salt; DNBSO sodium salt
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2,4-Dinitrobenzenesulfonic acid (DNBS; DNBSO) sodium salt (Sodium 2,4-dinitrobenzenesulfonate) is a classic colitis inducer that relies on activation of the NF-κB p65/COX-2/p38 pathway. As a hapten, 2,4-Dinitrobenzenesulfonic acid sodium salt stimulates the production of immune responses in colonic tissues, triggers oxidative stress and inflammatory reactions, and thereby leads to colonic injury. 2,4-Dinitrobenzenesulfonic acid sodium salt successfully induces models of colitis and ulcerative colitis in rats, causing pathological changes such as ulcers, edema, stenosis, shortening and organ adhesion in the distal colon, along with significant increases in the levels of inflammatory indicators and endoplasmic reticulum stress marker proteins. 2,4-Dinitrobenzenesulfonic acid sodium salt is widely used in studies on the mechanisms related to colitis and ulcerative colitis .
Cat. No.: HY-176806
CAS No.: 606967-53-7
Synonyms: Doxorubicin-LNAA-Boc
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Legubicin (Doxorubicin-LNAA-Boc) is a novel conjugate of Doxorubicin (HY-15142A) and a Legumain-cleavable peptide linker. Legubicin is activated by Legumain to release leucine-doxorubicin while sparing normal tissues. Legubicin inhibits tumor cell growth and reduces DNA binding in non-legumain expressing cells. Legubicin completely arrests tumor growth in mice bearing CT26 tumors. Legubicin can be used for the study of colon carcinoma (CRC) .
Vps34-IN-4 is an orally active and selective VPS34 inhibitor with an IC50 of 15 nM against human VPS34. Vps34-IN-4 binds to the ATP-binding pocket of VPS34. Vps34-IN-4 inhibits autophagy (autophagy) by blocking the degradation of autophagic substrates and increasing both lipidated and non-lipidated forms of LC3. Vps34-IN-4 induces time-dependent LC3-II accumulation in tumor tissues of tumor-bearing mice. Vps34-IN-4 can be used for research on cancers such as colon cancer .
Cat. No.: HY-W250120
CAS No.: 37220-17-0
Cat. No.: HY-N7695
CAS No.: 23133-56-4
Cat. No.: HY-N0666S2
CAS No.: 14341-75-4
Cat. No.: HY-P5107
CAS No.: 121052-30-0
Synonyms: LMWP; TDSP5
Cat. No.: HY-P99691
CAS No.: 250242-54-7
Synonyms: IMMU-MN3
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Cat. No.: HY-W343900
CAS No.: 6912-67-0
Synonyms: DL-Hydroxyproline
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Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagenous tissues. Hydroxyproline acts as a substrate for mitochondrial hydroxyproline oxidase to generate ROS. Hydroxyproline promotes the synthesis of glutathione, DNA, heme and proteins via conversion to Glycine (HY-Y0966). Hydroxyproline promotes the activation of caspase-9 and apoptosis in cancer cells treated with Doxorubicin . Hydroxyproline serves as a biochemical marker. Hydroxyproline is used in research related to various diseases including colon cancer, diabetes and arthritis .
Cat. No.: HY-162537
CAS No.: 2484876-99-3
LYP-8 is an intracellular nicotinamide phosphoribosyltransferase (iNAMPT) PROTAC degrader with an IC50 of 0.76 μM. LYP-8 recruits VHL E3 ligase to induce iNAMPT polyubiquitination and proteasome-dependent degradation, and inhibits iNAMPT enzymatic activity. LYP-8 reduces eNAMPT levels by degrading iNAMPT to decrease eNAMPT secretion. LYP-8 reduces intracellular NAD + levels in cancer cells and proinflammatory cytokine levels (IL-6, TNF-α) in tumor tissue and serum. LYP-8 can be used for the research of colon cancer .
Cat. No.: HY-P5107A
Synonyms: LMWP acetate; TDSP5 acetate
Cat. No.: HY-139062
CAS No.: 486991-52-0
Synonyms: C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea; D-erythro-Urea-C6-Ceramide
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C6 Urea Ceramide (Cer(d18:1/6:0) Urea) is an inhibitor of neutral ceramidase. C6 Urea Ceramide increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and HT-29 colon cancer cells. C6 Urea Ceramide (5-10 μM) inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but is not toxic to non-cancerous cells. C6 Urea Ceramide decreases total and phosphorylated β-catenin levels in HT-29 and HCT116 cells, and induces colocalization of β-catenin with the 20S proteasome. C6 Urea Ceramide (1.25, 2.5, and 5 mg/kg) reduced tumor growth and increased C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.
Cat. No.: HY-N0666DR
CAS No.: 5598-53-8
Synonyms: Disodium L-aspartate (Standard)
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Synonyms: Citronic acid (Standard); Methylfumaric acid (Standard)
Cat. No.: HY-P991619
CAS No.: 808771-06-4
Synonyms: TF8-5G9
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Cardiovascular Disease Metabolic Disease Inflammation/Immunology
SM19712 is an orally active, selective endothelin converting enzyme (ECE) inhibitor. SM19712 inhibits conversion of big ET-1 to ET-1. SM19712 attenuates colonic angiogenesis, tissue injury, inflammation, without altering colon shortening or myeloperoxidase levels in mice. SM19712 can be used for the research of inflammatory bowel disease (colitis), ischemic acute renal failure, acute myocardial infarction, and myocardial ischemia/reperfusion injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
