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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
111 Results for "
cruzi
" in MedChemExpress (MCE) Product Catalog:
Products (111)
111 Results for "cruzi" in MCE Product Catalog:
8
8 Publications Verification
DIF-3 is an orally active anticancer agent. DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in cells. DIF-3 induces reactive oxygen species (ROS) and autophagy. DIF suppresses the growth of Trypanosoma. cruzi in HT1080 cells. DIF-3 exerts antitumor effects both in vitro and in vivo .
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Dihydroergotamine mesylate is a blood-brain barrier-permeable semi-synthetic ergot alkaloid, acting as a full agonist of 5-HT1B/1D receptors (Ki values of 0.3 nM and 2.5 nM, respectively; functional IC50 values of 2 nM and 2.2 nM, respectively). Dihydroergotamine mesylate inhibits Forskolin (HY-15371)-stimulated cAMP accumulation, possesses α-adrenergic receptor antagonistic activity and weak dopaminergic agonistic activity. It mediates intracranial cerebrovascular contraction, inhibits the release of neuropeptides such as CGRP/substance P, and suppresses neurogenic inflammation by activating 5-HT1B/1D receptors in the trigeminovascular system. Dihydroergotamine mesylate binds to the catalytic site of Trypanosoma cruzi trypanothione reductase and exhibits trypanocidal activity in vitro. Dihydroergotamine mesylate can be used in studies related to migraine and trypanosome infections .
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4 Cited Publications
Research Areas:
K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively .
3
3 Cited Publications
Cat. No.: HY-B1548
CAS No.: 22994-85-0
Synonyms: Benznidazol; Ro 07-1051; Ro 71051
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Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease .
1
1 Cited Publications
Cat. No.: HY-W040073
CAS No.: 23256-30-6
Target:
Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
1
1 Cited Publications
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite .
1
Category:
Cardiovascular Disease Neurological Disease Capsicum annuum L. Extract Solanaceae Extract Infection Alkaloids Plant Other Alkaloids Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-W010538
CAS No.: 2523-55-9
trans-4-Methylcyclohexanamine is an organic amine compound that can be used in the development of T. cruzi enzyme inhibitors .
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Dendrobium chryseum Z. H. Tsi et S. C. Chen Extract Plant Orchidaceae Extract Simple Phenylpropanols Phenylpropanoids
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4-(Bromomethyl)benzoic acid (4-Carboxybenzyl bromide) is an antiparasitic agent with low activity against Leishmania amazonensis and Trypanosoma cruzi. 4-(Bromomethyl)benzoic acid has certain cytotoxicity to PBMCs, with an IC50 of 88.8 μM .
Cat. No.: HY-175741
CAS No.: 3094992-69-2
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IID432 is a potent, orally active, and covalent inhibitor of Trypanosoma cruzi topoisomerase II. IID432 shows an EC50 of 8 nM against T. cruzi intracellular amastigotes, exhibits excellent oral bioavailability (52% in rats), favorable ADME properties, and no S1P pathway modulation. IID432 achieves relapse-free cure in a chronic T. cruzi infection mouse model, can be used for the study of Chagas disease .
Cat. No.: HY-153238
CAS No.: 2152662-92-3
AN15368 is an orally active trypanocidal agent and a prodrug of AN14667. AN15368 selectively targets CPSF3-mediated mRNA maturation in intracellular amastigotes of Trypanosoma cruzi, reducing the mRNA levels of the parasite. As a prodrug, AN15368 can be cleaved into its active carboxylate form by CBP of Trypanosoma cruzi. AN15368 completely clears long-term naturally acquired Trypanosoma cruzi infections in non-human primates. AN15368 can be used in the research of Chagas disease .
Cat. No.: HY-128268
CAS No.: 735303-62-5
PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively .
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SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .
T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease .
Cat. No.: HY-N2656
CAS No.: 60796-65-8
Category:
Rutaceae Extract Plant Coumarins Phenylpropanoids Zanthoxylum dimorphophyllum Hemsl. Extract
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Cat. No.: HY-N7632
CAS No.: 21763-80-4
Category:
Flavones Compositae/Asteraceae Extract Other Families Extract Infection Plant Flavonoids Monophenols Artemisia princeps Pamp. Extract Phenols Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-151485
CAS No.: 2738381-47-8
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection .
Cat. No.: HY-119293A
CAS No.: 502960-91-0
Research Areas:
K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
