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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
curcumin derivative
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "curcumin derivative" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-N0007
CAS No.: 33171-05-0
Synonyms: (E,E)-curcumin III; (E,E)-Didemethoxycurcumin
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TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research .
Cat. No.: HY-N0894R
CAS No.: 36062-07-4
Synonyms: Hexahydrobisdemethoxycurcumin (Standard)
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Cat. No.: HY-N0007R
CAS No.: 33171-05-0
Synonyms: (E,E)-curcumin III (Standard); (E,E)-Didemethoxycurcumin (Standard)
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Cat. No.: HY-137315S
CAS No.: 2673270-28-3
Cat. No.: HY-15668
CAS No.: 1370037-59-4
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ST09 is an efficient and low toxicity Curcumin (HY-N0005) derivative. ST09 significantly inhibits cell migration and downregulates the expression of MMP1, MMP2, and Vimentin. ST09 has strong cytotoxicity to breast cancer cells, such as MDA-MB-231, MCF7 and T47D cells. ST09 induces cell apoptosis by upregulating Bax and cleaved caspase-3/9. ST09 can be used in the research of cancer such as breast cancer .
Cat. No.: HY-179228
CAS No.: 1246964-08-8
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AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer .
Cat. No.: HY-151342
CAS No.: 3032193-12-4
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Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .
Cat. No.: HY-120914
CAS No.: 170950-29-5
Synonyms: GO-Y015
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Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism Drug Derivative TrxR
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TrxR1-IN-B19 (GO-Y015) is a Curcumin (HY-N0005) derivative and TrxR1 inhibitor. TrxR1-IN-B19 inhibits de novo selenoprotein synthesis, suppresses SeP and GPx expression, and impairs selenium incorporation into Sec-tRNA[Sec]. TrxR1-IN-B19 induces Nrf2 accumulation through Keap1 cysteine modification, HO-1 expression, GSH synthesis, ROS accumulation, ER stress, mitochondrial dysfunction, Apoptosis, and G2/M phase arrest. TrxR1-IN-B19 improves glucose tolerance and insulin sensitivity, lowers blood glucose, inhibits tumor growth, and reduces arsenic accumulation. TrxR1-IN-B19 can be used for research on type 2 diabetes, arsenite-induced toxicity, and gastric cancer .
Cat. No.: HY-N12669
CAS No.: 387818-26-0
Cat. No.: HY-139804
CAS No.: 1297262-16-8
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CTK7A is a curcumin derivative with anticancer activity by inhibiting the HAT activity of p300 and reducing the autoacetylation of p300, thereby affecting its interaction with HIF-1α. The inhibition of CTK7A leads to decreased HIF-1α accumulation and activity, which can be used for cancer research .
Cat. No.: HY-D3429
CAS No.: 2700202-84-0
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Shiga-Y51 is a molecular probe that can cross the blood-brain barrier and selectively bind Aβ oligomers. Shiga-Y51 can be imaged based on fluorine-19 nuclear magnetic resonance imaging ( 19F-MRI) technology. Shiga-Y51 exhibits extremely strong binding affinity for early to intermediate Aβ oligomers, while having almost no affinity for mature Aβ fibrils. Shiga-Y51 is a derivative of Curcumin (HY-N0005) and can inhibit the binding of Curcumin to Aβ oligomers with an IC50 of 34.61 µM. Shiga-Y51 can be used in research related to Alzheimer's disease .
Cat. No.: HY-187991
FtsZ-IN-16 is a curcumin derivative and also an inhibitor of XooFtsZ, with an EC50 of 3.74 μg/mL against Xoo. FtsZ-IN-16 targets the FtsZ residues LEU71, GLY74, GLY110 and THR111 of Xanthomonas oryzae pv. oryzae, thereby blocking GTPase (GTPase) activity and polymerization. FtsZ-IN-16 can be used in studies related to rice bacterial blight .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
