36

MSA-2

36 Publications Verification

Cat. No.: HY-136927

CAS No.: 129425-81-6

Purity: 99.81%

Target:

STING

Research Areas:

Inflammation/Immunology Cancer

MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC₅₀s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models .

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16

SN-011

16 Cited Publications

Cat. No.: HY-145010

CAS No.: 2249435-90-1

Purity: 99.73%

Target:

STING

Research Areas:

Inflammation/Immunology

SN-011 is a potent and selective mouse and human STING inhibitor, with an IC₅₀ of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease .

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10

Glutathione oxidized

10 Cited Publications

Cat. No.: HY-D0844

CAS No.: 27025-41-8

Synonyms: L-Glutathione oxidized; GSSG; Oxiglutatione

Category:

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Reactive Oxygen Species (ROS)

Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .

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7

Tesirine

7 Cited Publications

Cat. No.: HY-128952

CAS No.: 1595275-62-9

Purity: 98.10%

Synonyms: SG3249

Target:

Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker

Research Areas:

Cancer

Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

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7

Demecolcine

7 Cited Publications

Cat. No.: HY-N0282

CAS No.: 477-30-5

Synonyms: Colcemid

Category:

Alkaloids Other Alkaloids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

Microtubule/Tubulin Apoptosis

Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

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7

HSP27 inhibitor J2

7 Cited Publications

Cat. No.: HY-124653

CAS No.: 2133499-85-9

Purity: 99.70%

Synonyms: J2

Target:

HSP

Research Areas:

Cancer

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .

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4

Tricarbonyldichlororuthenium(II) dimer

4 Cited Publications

Cat. No.: HY-W033577

CAS No.: 22594-69-0

Synonyms: CORM-2

Target:

P2X Receptor Potassium Channel NO Synthase STAT Interleukin Related

Research Areas:

Inflammation/Immunology

Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels .

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4

SG3199

4 Cited Publications

Cat. No.: HY-101161

CAS No.: 1595275-71-0

Purity: 98.94%

Target:

DNA Alkylator/Crosslinker ADC Payloads

Research Areas:

Cancer

SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .

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3

BI-0115

3 Cited Publications

Cat. No.: HY-23999

CAS No.: 4929-23-1

Target:

LOX-1

Research Areas:

Cardiovascular Disease

BI-0115 is a selective inhibitor of LOX-1 (IC₅₀=5.4 μM) that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain .

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3

Procyanidin A1

3 Cited Publications

Cat. No.: HY-N2344

CAS No.: 103883-03-0

Synonyms: Proanthocyanidin A1

Category:

Plants Other Families Extract Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Disease Research Fields Inflammation/Immunology Biflavones

Target:

PKC

Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca ²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

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3

IL-17A antagonist 1

3 Cited Publications

Cat. No.: HY-101913

CAS No.: 2205034-18-8

Purity: 99.74%

Target:

Interleukin Related

Research Areas:

Inflammation/Immunology Cancer

IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC₅₀ of 1.14 μM and a K_d of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA .

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2

Dixanthogen

2 Cited Publications

Cat. No.: HY-B1186

CAS No.: 502-55-6

Target:

Biochemical Assay Reagents Drug Derivative

Research Areas:

Others

Dixanthogen is a dimer of xanthate, which forms via the oxidation of xanthate. Dixanthogen can decompose peroxides, which are key radical initiators for the oxidative degradation of polypropylene. Dixanthogen serves as a stabilizer for polypropylene, a pediculicide, and is also used in studies related to metal recovery .

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2

Allophycocyanin

2 Cited Publications

Cat. No.: HY-D1815

Synonyms: APC Dye

Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .

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2

N,N'-Methylenebisacrylamide

2 Cited Publications

Cat. No.: HY-D0848

CAS No.: 110-26-9

Synonyms: Bisacrylamide; MBA; Methylenebisacrylamide; N,N-Methylenebisacrylamide

N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel .

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1

MSA-2 dimer

1 Cited Publications

Cat. No.: HY-141514

CAS No.: 2377881-92-8

Purity: 99.88%

Target:

STING

Research Areas:

Inflammation/Immunology Cancer

MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (K_d=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .

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