105 Results for "

dismutase

" in MedChemExpress (MCE) Product Catalog:
Products (105)

105 Results for "dismutase" in MCE Product Catalog:

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353
MitoSOX Red
MitoSOX Red
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353 Publications Verification
Cat. No.: HY-D1055
CAS No.: 1003197-00-9
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
Excitation/emission wavelength: 510/580 nm.
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49
Camostat
Camostat
0 Images
49 Cited Publications
Cat. No.: HY-165529
CAS No.: 59721-28-7
Target:  

Ser/Thr Protease

Research Areas:  

Inflammation/Immunology

Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs) .
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34
2-Methoxyestradiol
2-Methoxyestradiol
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34 Cited Publications
Cat. No.: HY-12033
CAS No.: 362-07-2
Purity:  99.76%
Synonyms: 2-ME2; NSC-659853
Category:  

Monophenols Disease markers Endocrine diseases Phenols Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Endogenous Metabolite Microtubule/Tubulin HIF/HIF Prolyl-Hydroxylase Cytochrome P450 JNK Caspase Estrogen Receptor/ERR Reactive Oxygen Species (ROS) Apoptosis Autophagy

2-Methoxyestradiol (2-ME2; NSC-659853) is an endogenous steroid metabolite generated from 17β-estradiol, possessing various activities such as antitumor and antiangiogenic effects. 2-Methoxyestradiol competitively binds to the colchicine-binding site of tubulin (tubulin), interfering with microtubule assembly dynamics. 2-Methoxyestradiol inhibits CYP1A1/CYP1B1, HIF-1α/2α, and superoxide dismutase, activates the JNK signaling pathway, elevates ROS levels, and induces cell cycle arrest and apoptosis (apoptosis). 2-Methoxyestradiol is used in cancer-related research, such as breast cancer, prostate cancer, and multiple myeloma .
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29
Tempol
Tempol
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29 Cited Publications
Cat. No.: HY-100561
CAS No.: 2226-96-2
Purity:  99.73%
Synonyms: 4-Hydroxy-TEMPO; MBM-02
Target:  

Reactive Oxygen Species (ROS) Autophagy

Research Areas:  

Inflammation/Immunology Cancer

Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS).
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17
NF-κΒ activator 1
NF-κΒ activator 1
0 Images
17 Cited Publications
Cat. No.: HY-134476
CAS No.: 2387524-59-4
Purity:  99.59%
Target:  

NF-κB

Research Areas:  

Inflammation/Immunology

NF-κΒ activator 1 (compound 32) is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD)2 mRNA expression .
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6
ATN-224
ATN-224
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6 Cited Publications
Cat. No.: HY-16074
CAS No.: 649749-10-0
Synonyms: Bischolinetetrathiomolybdate
Target:  

SOD

Research Areas:  

Cancer

ATN-224 is an orally active Cu 2+/Zn 2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5 nM.
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6
MnTBAP chloride
MnTBAP chloride
0 Images
6 Cited Publications
Cat. No.: HY-126397
CAS No.: 55266-18-7
Purity:  ≥98.0%
Target:  

NF-κB

Research Areas:  

Inflammation/Immunology

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research .
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5
Acetoacetic acid sodium
Acetoacetic acid sodium
0 Images
5 Cited Publications
Cat. No.: HY-112540B
CAS No.: 623-58-5
Purity:  ≥98.0%
Category:  

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Acetoacetic acid sodium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid sodium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid sodium can be used to study metabolic diseases .
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5
Acetoacetic acid
Acetoacetic acid
0 Images
5 Cited Publications
Cat. No.: HY-112540
CAS No.: 541-50-4
Category:  

Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite

Target:  

Endogenous Metabolite

Acetoacetic acid is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid can be used to study metabolic diseases .
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5
Acetoacetic acid lithium
Acetoacetic acid lithium
0 Images
5 Cited Publications
Cat. No.: HY-112540A
CAS No.: 3483-11-2
Purity:  ≥98.0%
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Acetoacetic acid lithium is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid lithium induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid lithium can be used to study metabolic diseases .
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4
CORM-3
CORM-3
0 Images
4 Cited Publications
Cat. No.: HY-100581
CAS No.: 475473-26-8
Purity:  ≥97.0%
Target:  

NF-κB NOD-like Receptor (NLR)

Research Areas:  

Inflammation/Immunology

CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation .
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4
LCS-1
LCS-1
0 Images
4 Cited Publications
Cat. No.: HY-115445
CAS No.: 41931-13-9
Purity:  99.81%
Target:  

Apoptosis SOD

Research Areas:  

Cancer

LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibits SOD1 activity with an IC50 value of 1.07 μM. LCS-1 induces the early- and late-stage apoptosis of multiple myeloma (MM.1S) cells .
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2
Tofersen
Tofersen
0 Images
2 Cited Publications
Cat. No.: HY-132580
CAS No.: 2088232-70-4
Purity:  96.53%
Synonyms: BIIB067; ISIS-SOD1Rx; ISIS 333611
Target:  

SOD

Research Areas:  

Neurological Disease

Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
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2
Superoxide dismutase, Porcine erythrocytes
Superoxide dismutase, Porcine erythrocytes
0 Images
2 Cited Publications
Cat. No.: HY-129064
CAS No.: 9054-89-1
Synonyms: SOD
Target:  

SOD

Research Areas:  

Inflammation/Immunology Cancer

Superoxide dismutase, Porcine erythrocytes (SOD) is the only antioxidant enzyme that scavenges the superoxide anion by converting this free radical to oxygen and hydrogen peroxide, thus preventing peroxynitrite production and further damage. Superoxide dismutase, Porcine erythrocytes is extensively researched and used in anti-inflammatory, antitumor, radiation protection, and antisenility applications .
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2
Tofersen sodium
Tofersen sodium
0 Images
2 Cited Publications
Cat. No.: HY-132580A
CAS No.: 1898254-60-8
Purity:  97.19%
Synonyms: BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium
Target:  

SOD

Research Areas:  

Neurological Disease

Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
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2
Manganese(salen) chloride
Manganese(salen) chloride
0 Images
2 Cited Publications
Cat. No.: HY-W001583
CAS No.: 53177-12-1
Synonyms: EUK-8
Target:  

Reactive Oxygen Species (ROS)

Research Areas:  

Cardiovascular Disease

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine .
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2
Superoxide dismutase PEG
Superoxide dismutase PEG
0 Images
2 Cited Publications
Cat. No.: HY-129064B
Target:  

SOD

Research Areas:  

Metabolic Disease

Superoxide dismutase PEG (EC 1.15.1.1) is a mimetic of superoxide dismutase (SOD) and powerful free radical scavenger acts by reducing superoxide anions .
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1
Hydroxycitric acid
Hydroxycitric acid
0 Images
1 Cited Publications
Cat. No.: HY-N1437
CAS No.: 6205-14-7
Category:  

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