29

Epacadostat

29 Publications Verification

Cat. No.: HY-15689

CAS No.: 1204669-58-8

Purity: 98.47%

Synonyms: INCB 024360

Target:

Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Inflammation/Immunology Cancer

Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC₅₀ of 71.8 nM . Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.

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10

Incomplete Freund's adjuvant (IFA)

10 Cited Publications

Cat. No.: HY-153808A

Target:

Bacterial

Research Areas:

Inflammation/Immunology Cancer

Incomplete Freund's adjuvant (IFA) (Montanide ISA-51) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund. Incomplete Freund's adjuvant (IFA) does not contain inactivated tuberculosis bacilli and consists of petroleum jelly containing lanolin. Incomplete Freund's adjuvant (IFA) induces high antibody titers and long-lasting effector T cell responses with no long-term effects on collagen disease, tumors, or death. Complete Freund's adjuvant (CFA) (HY-153808) is another type of Freund's Adjuvant that stimulates a stronger immune response .

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6

BMS-1166

6 Cited Publications

Cat. No.: HY-102011

CAS No.: 1818314-88-3

Purity: 99.49%

Target:

PD-1/PD-L1

Research Areas:

Inflammation/Immunology Cancer

BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC₅₀ of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation .

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6

BMS-1166 hydrochloride

6 Cited Publications

Cat. No.: HY-102011A

CAS No.: 2113650-05-6

Purity: 99.31%

Target:

PD-1/PD-L1

Research Areas:

Inflammation/Immunology Cancer

BMS-1166 hydrochloride is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 hydrochloride induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC₅₀ of 1.4 nM. BMS-1166 hydrochloride antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation .

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5

HSA Protein

5 Cited Publications

Cat. No.: HY-P1956

CAS No.: 70024-90-7

Synonyms: Human serum albumin

Target:

NF-κB NO Synthase

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

HSA Protein (Human serum albumin) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. HSA Protein exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. HSA Protein can block the inhibitory effect of GML on human T cells, providing protective function for T cells. HSA Protein is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ^-) in the vascular wall, contributing to the reduction of blood pressure .
This product is recombinant HSA Protein expressed in a microbial expression system.

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3

Soquelitinib

3 Cited Publications

Cat. No.: HY-150298

CAS No.: 2226636-04-8

Purity: 99.71%

Synonyms: CPI-818

Target:

Itk

Research Areas:

Inflammation/Immunology Cancer

Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytokine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 ⁺ cells that possess enhanced T effector function .

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3

STM3006

3 Cited Publications

Cat. No.: HY-156773

CAS No.: 2499664-52-5

Purity: 98.71%

Target:

Apoptosis METTL3

Research Areas:

Cancer

STM3006 is a highly potent, selective, and orally active inhibitor of METTL3 (IC₅₀: 5 nM). STM3006 can reduce the m6A level, promote the formation of dsRNA, trigger a cell-intrinsic interferon response, and enhance the killing effect of T cells on tumors. STM3006 has anti-tumor activity, and its combination with anti-PD-1 immunotherapy yields better results .

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3

PRN694

3 Cited Publications

Cat. No.: HY-12680

CAS No.: 1575818-46-0

Purity: 98.09%

Target:

Itk

Research Areas:

Inflammation/Immunology

PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC₅₀s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo .

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2

Tinurilimab

2 Cited Publications

Cat. No.: HY-P99051

CAS No.: 2226224-30-0

Synonyms: BAY 1834942

Tinurilimab (Bay 1834942) is an anti-CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) humanized IgG2 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors. Tinurilimab shows an increased tumor cell killing effect in the tumor-cell/T-cell co-culture system .

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2

CA-170

2 Cited Publications

Cat. No.: HY-101093

CAS No.: 1673534-76-3

Purity: 99.39%

Target:

PD-1/PD-L1

Research Areas:

Inflammation/Immunology Cancer

CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .

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2

Mocravimod

2 Cited Publications

Cat. No.: HY-109038

CAS No.: 509092-16-4

Synonyms: KRP-203 free base

Target:

LPL Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Akt GSK-3 JAK STAT

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

Mocravimod (KRP-203 free base) is a sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3. Mocravimod retains T cell effector function. Mocravimod can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) .

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2

Mocravimod hydrochloride

2 Cited Publications

Cat. No.: HY-13660

CAS No.: 509088-69-1

Purity: 99.68%

Synonyms: KRP-203

Target:

LPL Receptor Reactive Oxygen Species (ROS) Akt GSK-3 JAK STAT

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

Mocravimod (hydrochloride) is an orally active sphingosine-1-phosphate receptor (S1PR) modulator that blocks the signal required by T cells to egress from lymph nodes and other lymphoid organs. Mocravimod (hydrochloride) preferentially binds to S1PR1 over S1PR2 and S1PR3 in cardiomyocytes. Mocravimod (hydrochloride) significantly lowered the concentration of reactive oxygen species (ROS), prevented mitochondrial permeability transition pore opening, boosted mitochondrial membrane potential (MMP), and increased phosphorylation of AKT, EKR, GSK-3β, JAK2, and STAT3. Mocravimod (hydrochloride) retains T cell effector function. Mocravimod (hydrochloride) can be used for the study of acute myelogenous leukemia, diabetes and Myocardial Ischemia-Reperfusion Injury (MIRI) .

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2

HSA Protein (Cell culture grade, Endotoxin<0.125 EU/mg)

2 Cited Publications

Cat. No.: HY-P1956A

CAS No.: 70024-90-7

Synonyms: Human serum albumin (cell culture grade, Endotoxin<0.125 EU/mg)

Target:

NF-κB NO Synthase

Research Areas:

Cardiovascular Disease Inflammation/Immunology

HSA Protein (Cell culture grade, Endotoxin<0.125 EU/mg) (Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. HSA Protein (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. HSA Protein (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. HSA Protein (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ^-) in the vascular wall, contributing to the reduction of blood pressure. HSA Protein (Cell culture grade, Endotoxin<0.125 EU/mg) can be used for in vitro cell culture .
This product is human serum albumin recombinantly expressed in an Escherichia coli expression system.

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1

Mosunetuzumab

1 Cited Publications

Cat. No.: HY-P99033

CAS No.: 1905409-39-3

Synonyms: BTCT-4465A; RG-7828; RO7030816

Target:

CD20 CD3

Research Areas:

Cancer

Mosunetuzumab (BTCT-4465A) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs). The Fc region of Mosunetuzumab incorporates a "knob-into-hole" structural modification and an N297G point mutation to achieve heterodimerization and eliminate Fc glycosylation, thereby effectively silencing antibody effector functions .

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