5

Thioacetamide

5 Cited Publications

Cat. No.: HY-Y0698

CAS No.: 62-55-5

Synonyms: Acetothioamide; TAA; Thiacetamide

Target:

Necroptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model .

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3

Gln-AMS

3 Cited Publications

Cat. No.: HY-112861

CAS No.: 209543-57-7

Purity: 99.21%

Target:

Aminoacyl-tRNA Synthetase Apoptosis Ferroptosis Reactive Oxygen Species (ROS)

Research Areas:

Endocrinology Cancer

Gln-AMS is a potent inhibitor of Aminoacyl-tRNA Synthetase. Gln-AMS blocks the lactylation modification of downstream targets through competitive binding to AARS1, thereby regulating apoptosis, ferroptosis, and the transcriptional processes of related genes. Gln-AMS can be used in research on breast cancer, diabetic nephropathy, and sepsis-associated encephalopathy .

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3

Gln-AMS TFA

3 Cited Publications

Cat. No.: HY-112861A

Purity: 99.65%

Target:

Aminoacyl-tRNA Synthetase Apoptosis Ferroptosis Reactive Oxygen Species (ROS)

Gln-AMS TFA is a potent inhibitor of Aminoacyl-tRNA Synthetase. Gln-AMS TFA blocks the lactylation modification of downstream targets through competitive binding to AARS1, thereby regulating apoptosis, ferroptosis, and the transcriptional processes of related genes. Gln-AMS TFA can be used in research on breast cancer, diabetic nephropathy, and sepsis-associated encephalopathy .

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2

Dexpramipexole dihydrochloride

2 Cited Publications

Cat. No.: HY-17355A

CAS No.: 104632-27-1

Synonyms: (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride

Target:

ATP Synthase Sodium Channel Glutathione Peroxidase NOD-like Receptor (NLR) Mitophagy Ferroptosis PINK1/Parkin Autophagy Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na_v1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more .

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2

Tolperisone hydrochloride

2 Cited Publications

Cat. No.: HY-B1139

CAS No.: 3644-61-9

Target:

Apoptosis

Research Areas:

Neurological Disease

Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity .

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