Oops!

STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

14

Baloxavir marboxil

14 Cited Publications

Cat. No.: HY-109025

CAS No.: 1985606-14-1

Purity: 99.96%

Synonyms: S-033188; RG 6152

Target:

Influenza Virus

Research Areas:

Infection

Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

9

FEN1-IN-1

9 Cited Publications

Cat. No.: HY-123834

CAS No.: 824983-91-7

Purity: 99.85%

Target:

FLAP ATM/ATR

Research Areas:

Endonuclease DNA/RNA Synthesis

FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg ²⁺ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

7

RNase A, Bovine pancreas

7 Cited Publications

Cat. No.: HY-129046

CAS No.: 9001-99-4

Synonyms: Ribonuclease A; EC 4.6.1.18; RNase A

Target:

Research Areas:

RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

PFM01

6 Cited Publications

Cat. No.: HY-116770

CAS No.: 1558598-41-6

Purity: 99.91%

Target:

Research Areas:

PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

PFM03

5 Cited Publications

Cat. No.: HY-148078

CAS No.: 1558598-48-3

Purity: 99.86%

Target:

Research Areas:

PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

FEN1-IN-SC13

4 Cited Publications

Cat. No.: HY-145758

CAS No.: 2098776-03-3

Purity: 98.21%

Target:

Research Areas:

DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species (ROS)

FEN1-IN-SC13 is a potent DNA fragmentation endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-SC13 interferes with DNA replication and repair in vitro and in cells .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

Erenapurstat

4 Cited Publications

Cat. No.: HY-19357

CAS No.: 136164-66-4

Synonyms: E3330; APX-3330

Target:

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Erenapursta (E3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. Erenapursta is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. Erenapursta shows anticancer activities .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

CRT0044876

3 Cited Publications

Cat. No.: HY-W014622

CAS No.: 6960-45-8

Target:

DNA/RNA Synthesis

Research Areas:

CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC₅₀=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

FEN1-IN-4

3 Cited Publications

Cat. No.: HY-136485

CAS No.: 1995893-58-7

Purity: 99.86%

Target:

FLAP

Research Areas:

FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Deoxyribonuclease II

2 Cited Publications

Cat. No.: HY-P2863

CAS No.: 9025-64-3

Synonyms: DNase II

Target:

Research Areas:

Deoxyribonuclease II (DNase II) is an endonuclease that hydrolyzes the phosphodiester bonds of deoxyribonucleotides in native and denatured DNA, producing 3' phosphate and 5'-hydroxyl termini. Deoxyribonuclease II works best at acidic pH and is commonly used in biochemical research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

PFM39

2 Cited Publications

Cat. No.: HY-120951

CAS No.: 1310744-67-2

Purity: 99.01%

Target:

Research Areas:

PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

FEN1-IN-2

2 Cited Publications

Cat. No.: HY-122695

CAS No.: 824983-94-0

Purity: 99.94%

Target:

FLAP

Research Areas:

DNA/RNA Synthesis DNA Alkylator/Crosslinker Parasite IFNAR

FEN1-IN-2 (compound 20) is a flap endonuclease 1 (FEN1) inhibitor, with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Hycanthone

2 Cited Publications

Cat. No.: HY-B1099

CAS No.: 3105-97-3

Target:

Hycanthone is an apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor, DNA intercalator and Antischistosomal agent, with an IC₅₀ of 80 nM against APE1. Hycanthone irreversibly inhibits thymidine incorporation into DNA in adult sensitive *Schistosoma mansoni*, while exerts weak inhibitory effects on uridine and leucine incorporation. Hycanthone reduces influenza virus-induced interferon production. Hycanthone exhibits mutagenic effects in various organisms, shows teratogenicity in mice and rabbits, and induces neoplastic liver lesions in partially hepatectomized mice. Hycanthone can be used in research related to schistosomiasis and cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

DEPC-Treated Water

1 Cited Publications

Cat. No.: HY-156262

DEPC-Treated Water is ultrapure water that has been sterilized by high temperature and high pressure and does not contain nuclease. It can avoid contamination by non-specific endonucleases and exonucleases and does not affect RNase activity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

APE Protein, Human

1 Cited Publications

Cat. No.: HY-P7523

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: APEX1; APE1; Prev. APEX; DNA-(Apurinic Or Apyrimidinic Site) endonuclease; APEN; APEX Nuclease; REF-1; APEX Nuclease (Multifunctional DNA Repair Enzyme); REF1; Deoxyribonuclease (Apurinic Or Apyrimidinic); HAP1; Apurinic/Apyrimidinic (Abasic) endonuclease

Species:

Human

Source:

E. coli

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Nuclease P1

1 Cited Publications

Cat. No.: HY-P2963

CAS No.: 54576-84-0

Target:

Research Areas: