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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
ereblon
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "ereblon" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: Cereblon ligand 3; E3 ligase Ligand 3
Target:
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Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs .
1
1 Cited Publications
Homo-PROTAC cereblon degrader 1 is a highly selective cereblon (CRBN) PROTAC degrader. Homo-PROTAC cereblon degrader 1 induces self-directed ubiquitination and proteasomal degradation of CRBN. Homo-PROTAC cereblon degrader 1 blocks Pomalidomide (HY-10984)-induced degradation of IKZF1 and IKZF3. Homo-PROTAC cereblon degrader 1 antagonizes the growth inhibitory effect of Pomalidomide on multiple myeloma cells. Homo-PROTAC cereblon degrader 1 can be used in studies related to multiple myeloma .
1
1 Cited Publications
Synonyms: Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18
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Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker .
1
1 Cited Publications
Synonyms: Cereblon Ligand -Linker Conjugates 2 TFA; E3 Ligase Ligand-Linker Conjugates 20 TFA
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Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
1
1 Cited Publications
Cat. No.: HY-P702820
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein Cereblon; Cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A
Species:
Human
Source:
E. coli
Synonyms: Cereblon ligand 2; E3 ligase Ligand 2
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Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .
Cat. No.: HY-41547
CAS No.: 835616-60-9
Synonyms: Cereblon ligand 4; E3 ligase Ligand 4
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Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) .
Synonyms: Cereblon Ligand-Linker Conjugates 5 hydrochloride; E3 ligase Ligand-Linker Conjugates 30 hydrochloride
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Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology .
Cat. No.: HY-21930
CAS No.: 2097938-44-6
Synonyms: Cereblon Ligand -Linker Conjugates 1; E3 Ligase Ligand-Linker Conjugates 1
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Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
Synonyms: Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50
Research Areas:
Pomalidomide-PEG1-C2-N3 (Cereblon Ligand-Linker Conjugates 13) is a cereblon E3 ligand-linker conjugate that can be used to synthesisi selective CDK6 PROTAC degrader CP-10 (HY-125835). Pomalidomide-PEG1-C2-N3 can be used for the research of cancers .
Synonyms: Cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA
Research Areas:
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
Synonyms: Cereblon Ligand-Linker Conjugates 15 hydrochloride
Research Areas:
Pomalidomide-C2-NH2 (Cereblon Ligand-Linker Conjugate 15) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating agent. Cereblon inhibitor 1 has the potential for cancer research.
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Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor useful in solid tumor research, especially breast cancer .
Synonyms: Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride
Research Areas:
Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively .
Synonyms: Cereblon Ligand-Linker Conjugates 8; E3 Ligase Ligand-Linker Conjugates 22
Research Areas:
Pomalidomide-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
Synonyms: Cereblon Ligand-Linker Conjugates 6 TFA; E3 ligase Ligand-Linker Conjugates 19 TFA
Research Areas:
Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
Synonyms: Cereblon Ligand-Linker Conjugates 5 TFA ; E3 ligase Ligand-Linker Conjugates 30 TFA
Research Areas:
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs .
Synonyms: Cereblon ligand-linker Conjugate
Research Areas:
Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-acetylene-C5-COOH can be connected to the ligand for protein by a linker to form PROTAC . Lenalidomide-acetylene-C5-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Synonyms: Cereblon Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 15
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Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
