2

Cathepsin B Protein, Mouse (HEK293, His)

2 Cited Publications

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CTSB; Keratolytic Winter erythema (Oudtshoorn Skin Disease); Cathepsin B; Epididymis Secretory Sperm Binding Protein; APP Secretase; Amyloid Precursor Protein Secretase; Cathepsin B1; Cysteine Protease; APPS; RECEUP; CPSB; KWE

Species:

Mouse

Source:

HEK293

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2

Cathepsin B Protein, Human (HEK293, His)

2 Cited Publications

Cat. No.: HY-P7993A

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CTSB; Keratolytic Winter erythema (Oudtshoorn Skin Disease); Cathepsin B; Epididymis Secretory Sperm Binding Protein; APP Secretase; Amyloid Precursor Protein Secretase; Cathepsin B1; Cysteine Protease; APPS; RECEUP; CPSB; KWE

Species:

Human

Source:

HEK293

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1

Fenbufen

1 Cited Publications

Cat. No.: HY-B1138

CAS No.: 36330-85-5

Synonyms: CL-82204

Target:

COX Caspase

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .

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1

Carbinoxamine maleate salt

1 Cited Publications

Cat. No.: HY-B1589A

CAS No.: 3505-38-2

Target:

Histamine Receptor Influenza Virus

Research Areas:

Infection Inflammation/Immunology

Carbinoxamine maleate salt is a blood-brain barrier-permeable histamine H1 receptor antagonist. Carbinoxamine maleate salt blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. Carbinoxamine maleate salt inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. Carbinoxamine maleate salt can be used in research on allergic rhinitis, influenza, etc.

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1

(2E)-Diethyl fumarate

1 Cited Publications

Cat. No.: HY-W010056

CAS No.: 623-91-6

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Keap1-Nrf2

Diethyl fumarate is a Nrf2 inducer. Diethyl fumarate induces non-immunological contact urticaria, causing erythema, edema, and dose-dependent skin responses characterized by rapid onset, peak response, and subsequent resolution. The hybrid of Diethyl fumarate and Curcumin (HY-N0005) exerts neuroprotective effects. Diethyl fumarate can be used in the research of Parkinson's disease and non-immunological contact urticaria .

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1

Cathepsin B Protein, Human (L26V, HEK293, His)

1 Cited Publications

Cat. No.: HY-P78682

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CTSB; Keratolytic Winter erythema (Oudtshoorn Skin Disease); Cathepsin B; Epididymis Secretory Sperm Binding Protein; APP Secretase; Amyloid Precursor Protein Secretase; Cathepsin B1; Cysteine Protease; APPS; RECEUP; CPSB; KWE

Species:

Human

Source:

HEK293

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Poloxamer 184 (L64)

Cat. No.: HY-D1005A10

CAS No.: 9003-11-6

Synonyms: PEG-PPG-PEG, 2900 (Average)

Poloxamer 184 L64 is a block copolymer of polyethylene oxide and polypropylene oxide with an average molecular weight of 2900. Poloxamer has the ability to inhibit P-gp. Poloxamer 184 exhibits short-term skin toxicity, characterized by mild erythema and intradermal inflammatory reactions. Poloxamer 184 has antimicrobial activity, inhibiting 60% of Mycobacterium avium at a concentration of 1 mg/mL. Poloxamer 184 forms a thermoreversible hydrogel and is used as a food additive and as a drug delivery carrier in cosmetics and tissue engineering .

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Cysteine peptide

Cat. No.: HY-P10533

CAS No.: 845727-64-2

Target:

Tyrosinase

Research Areas:

Others

Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .

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Ceramide 3

Cat. No.: HY-141582

CAS No.: 34354-88-6

Purity: ≥98.0%

Synonyms: N-Stearoyl phytosphingosine

Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin .

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Methyl nicotinate

Cat. No.: HY-B1695

CAS No.: 93-60-7

Synonyms: Nicotinic acid methyl ester

Category:

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:

Others

Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

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Ufenamate

Cat. No.: HY-100009

CAS No.: 67330-25-0

Purity: 99.89%

Synonyms: Flufenamic acid butyl ester; Butyl flufenamate

Target:

COX Prostaglandin Receptor

Research Areas:

Inflammation/Immunology

Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug that can be used in the study of skin diseases such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliary rashes and atopic dermatitis. Ufenamate has a certain photoprotective effect, reduces the degree of skin erythema and swelling in the photoaging model, downregulates the expression level of COX-2 and can promote the healing of mouse skull defects by secreting BMP2 .

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Hydrocortisone aceponate

Cat. No.: HY-116691

CAS No.: 74050-20-7

Purity: 99.43%

Synonyms: Hydrocortisone 17-propionate 21-acetate

Target:

Glucocorticoid Receptor

Research Areas:

Neurological Disease Inflammation/Immunology

Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is a diester-based topical glucocorticoid. Hydrocortisone aceponate alleviates symptoms such as erythema, dryness/desquamation, pruritus, epidermal exfoliation, and exudation/crusting. Hydrocortisone aceponate causes extremely few adverse reactions. Hydrocortisone aceponate is applicable to various dermatological disease studies .

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Acetylsalicylsalicylic acid

Cat. No.: HY-W087907

CAS No.: 530-75-6

Target:

Drug Intermediate

Research Areas:

Inflammation/Immunology

Acetylsalicylsalicylic acid exhibits immunogenicity that induces contact sensitivity and causes skin erythema and slight edema in guinea pigs .

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Methyl nicotinate (Standard)

Cat. No.: HY-B1695R

CAS No.: 93-60-7

Synonyms: Nicotinic acid methyl ester (Standard)

Category:

Natural Products Microorganisms

Target:

Reference Standards Others

Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

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Ceramide 3-d3

Cat. No.: HY-141582S

CAS No.: 1354806-91-9

Synonyms: N-Stearoyl phytosphingosine-d₃

Ceramide 3-d₃ (N-Stearoyl phytosphingosine-d₃) is deuterium labeled Ceramide 3. Ceramide 3 is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.

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Hydrocortisone aceponate (Standard)

Cat. No.: HY-116691R

CAS No.: 74050-20-7

Synonyms: Hydrocortisone 17-propionate 21-acetate (Standard)

Target:

Reference Standards Glucocorticoid Receptor

Research Areas:

Neurological Disease Inflammation/Immunology

Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) Standard is the analytical standard of Hydrocortisone aceponate (HY-116691). This product is intended for research and analytical applications. Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is a diester-based topical glucocorticoid. Hydrocortisone aceponate alleviates symptoms such as erythema, dryness/desquamation, pruritus, epidermal exfoliation, and exudation/crusting. Hydrocortisone aceponate causes extremely few adverse reactions. Hydrocortisone aceponate is applicable to various dermatological disease studies .

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Linalyl isobutyrate

Cat. No.: HY-W472451

CAS No.: 78-35-3

Category:

Rutaceae Extract Other Monoterpenes Terpenoids Plants 500 - Internal Server Error | MedChemExpress

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