31

Folic acid disodium

31 Cited Publications

Cat. No.: HY-16637D

CAS No.: 29704-76-5

Synonyms: Vitamin B9 disodium; Vitamin M disodium

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite DNA/RNA Synthesis

Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 ⁵ g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .

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7

NADP sodium salt

7 Cited Publications

Cat. No.: HY-F0002

CAS No.: 1184-16-3

Synonyms: Sodium NADP

Target:

Endogenous Metabolite

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

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7

NADP disodium salt

7 Cited Publications

Cat. No.: HY-F0002A

CAS No.: 24292-60-2

Synonyms: Disodium NADP

Category:

Microorganisms Animals Ketones, Aldehydes, Acids Other Diseases Plants Other Families Extract Disease Research Fields

Target:

Endogenous Metabolite

NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

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7

NADP

7 Cited Publications

Cat. No.: HY-113325

CAS No.: 53-59-8

Purity: 99.70%

Category:

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

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7

NADP sodium hydrate

7 Cited Publications

Cat. No.: HY-113325A

CAS No.: 698999-85-8

Purity: 99.03%

Category:

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

NADP sodium hydrate is the sodium salt hydrate form of NADP (HY-113325). NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes .

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6

Choline chloride

6 Cited Publications

Cat. No.: HY-B1337

CAS No.: 67-48-1

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

Histamine Receptor

Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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6

Choline (bitartrate)

6 Cited Publications

Cat. No.: HY-101036

CAS No.: 87-67-2

Purity: ≥98.0%

Category:

Animals Ketones, Aldehydes, Acids

Target:

Histamine Receptor

Choline bitartrate (Oxtriphylline) is an orally active methylxanthine-derived choline salt of theophylline. Choline bitartrate exhibits weak antihistaminic and anticholinergic activities and can enhance the effects of histamine and acetylcholine. Choline bitartrate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates central nervous system motor activity, and induces transient hypotension following a pressor phase. Choline bitartrate modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline bitartrate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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6

Choline theophyllinate

6 Cited Publications

Cat. No.: HY-B1718

CAS No.: 4499-40-5

Synonyms: Oxtriphylline

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Histamine Receptor

Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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5

Thioacetamide

5 Cited Publications

Cat. No.: HY-Y0698

CAS No.: 62-55-5

Synonyms: Acetothioamide; TAA; Thiacetamide

Target:

Necroptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model .

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5

Clodronic acid disodium salt

5 Cited Publications

Cat. No.: HY-B0657A

CAS No.: 22560-50-5

Synonyms: Clodronate disodium salt

Target:

Apoptosis

Research Areas:

Metabolic Disease Cancer

Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis .

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5

Clodronic acid

5 Cited Publications

Cat. No.: HY-B0657

CAS No.: 10596-23-3

Synonyms: Clodronate

Target:

Apoptosis

Research Areas:

Metabolic Disease Cancer

Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis .

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3

Choline-d9 chloride

3 Cited Publications

Cat. No.: HY-B1337S1

CAS No.: 61037-86-3

Target:

Isotope-Labeled Compounds Histamine Receptor

Choline-d₉ chloride is the d₉-labeled Choline chloride (HY-B1337). Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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3

AUNP-12

3 Cited Publications

Cat. No.: HY-P1812

CAS No.: 1353563-85-5

Synonyms: NP-12

Target:

PD-1/PD-L1

Research Areas:

Cancer

AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) .

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3

AUNP-12 TFA

3 Cited Publications

Cat. No.: HY-P1812A

Synonyms: NP-12 TFA

Target:

PD-1/PD-L1

Research Areas:

Cancer

AUNP-12 TFA (NP-12 TFA) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. AUNP-12 TFA exhibits immune activation, excellent antitumor activity, and potential for better management of immune-related adverse events (irAEs) .

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2

Choline Chloride-13C3

2 Cited Publications

Cat. No.: HY-B1337S4

Target:

Isotope-Labeled Compounds Histamine Receptor

Choline Chloride- ¹³C₃ is the ¹³C-labeled Choline chloride (HY-B1337). Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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2

Syntide 2 TFA

2 Cited Publications

Cat. No.: HY-P0271A

Target:

CaMK

Research Areas:

Neurological Disease

Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

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