56

Elexacaftor

56 Publications Verification

Cat. No.: HY-111772

CAS No.: 2216712-66-0

Purity: 99.74%

Synonyms: VX-445

Target:

CFTR Autophagy

Research Areas:

Inflammation/Immunology

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .

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31

Oxytocin

31 Cited Publications

Cat. No.: HY-17571

CAS No.: 50-56-6

Synonyms: α-Hypophamine; Oxytocic hormone

Category:

Natural Products Monophenols Animals Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:

Oxytocin Receptor Endogenous Metabolite

Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

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31

Oxytocin acetate

31 Cited Publications

Cat. No.: HY-17571A

CAS No.: 6233-83-6

Synonyms: α-Hypophamine acetate; Oxytocic hormone acetate

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Oxytocin Receptor Endogenous Metabolite

Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .

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21

Cholic acid

21 Cited Publications

Cat. No.: HY-N0324

CAS No.: 81-25-4

Category:

Human Gut Microbiota Metabolites Microorganisms Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite

Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

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21

Cholic acid sodium

21 Cited Publications

Cat. No.: HY-N0324A

CAS No.: 361-09-1

Synonyms: Sodium cholate

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite

Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active .

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18

Glycine

18 Cited Publications

Cat. No.: HY-Y0966

CAS No.: 56-40-6

Category:

Neurological Disease Amino acids Endogenous metabolite Disease Research Fields

Target:

Ninjurin PROTAC Linkers VEGFR Endogenous Metabolite iGluR

Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine inhibits the membrane aggregation of NINJ1 and prevents plasma membrane rupture during cell death. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .

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14

CBL0137

14 Cited Publications

Cat. No.: HY-18935

CAS No.: 1197996-80-7

Synonyms: Curaxin 137; CBL-C137

Target:

Histone Acetyltransferase MDM-2/p53 NF-κB

Research Areas:

Cancer

CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF-κB and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis .

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14

α-Cyano-4-hydroxycinnamic acid

14 Cited Publications

Cat. No.: HY-107641

CAS No.: 28166-41-8

Purity: 99.92%

Synonyms: α-Cyano-4-hydroxycinnamate

Target:

Monocarboxylate Transporter

Research Areas:

Metabolic Disease

α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a K_i of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications .

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9

Vepdegestrant

9 Cited Publications

Cat. No.: HY-138642

CAS No.: 2229711-68-4

Purity: 99.60%

Synonyms: ARV-471; PF-07850327

Target:

PROTACs Estrogen Receptor/ERR

Research Areas:

Cancer

Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC₅₀) of about 2 nM .

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