9 Results for "

fibrotic processes

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "fibrotic processes" in MCE Product Catalog:

2
GSK 3008348
GSK 3008348
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2 Cited Publications
Cat. No.: HY-19767
CAS No.: 1629249-33-7
Target:  

Integrin TGF-β Receptor

Research Areas:  

Infection Inflammation/Immunology Cancer

GSK 3008348 is a small molecule antagonist of integrin αvβ6 with IC50 values for αvβ6, αvβ1, αvβ3, αvβ5, and αvβ8 are 1.50, 2.83, 12.53, 4.00, and 2.26 nM, respectively. GSK 3008348 can target the αvβ6 integrin, inhibit TGF-β activation, and thereby alleviate the fibrotic process. GSK 3008348 prevents the binding of the foot-and-mouth disease virus (FMDV) to the αvβ6 integrin receptor on the surface of host cells, thereby inhibiting the entry of the virus. GSK 3008348 can be used for research on pulmonary fibrosis and various types of cancer .
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GSK 3008348 hydrochloride
GSK 3008348 hydrochloride
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2 Cited Publications
Cat. No.: HY-19767A
CAS No.: 1629249-40-6
Target:  

Integrin TGF-β Receptor

Research Areas:  

Infection Inflammation/Immunology Cancer

GSK 3008348 hydrochloride is a small molecule antagonist of integrin αvβ6 with IC50 values for αvβ6, αvβ1, αvβ3, αvβ5, and αvβ8 are 1.50, 2.83, 12.53, 4.00, and 2.26 nM, respectively. GSK 3008348 hydrochloride can target the αvβ6 integrin, inhibit TGF-β activation, and thereby alleviate the fibrotic process. GSK 3008348 hydrochloride prevents the binding of the foot-and-mouth disease virus (FMDV) to the αvβ6 integrin receptor on the surface of host cells, thereby inhibiting the entry of the virus. GSK 3008348 hydrochloride can be used for research on pulmonary fibrosis and various types of cancer .
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BI-765423
BI-765423
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Cat. No.: HY-P991488

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

BI-765423 is a selective monoclonal antibody inhibitor targeting IL-11. BI-765423 blocks IL-11-mediated signaling, inhibits fibroblast activation, and can extend the healthy lifespan of mammals, counteract cellular senescence in human cells, and alleviate inflammatory aging-related pathological processes. BI-765423 is primarily used in research on fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) .
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MMI-0100
MMI-0100
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Cat. No.: HY-P3412
CAS No.: 1039342-24-9
Synonyms: MK2i peptide; YARA-MK2i
Target:  

MAPKAPK2 (MK2)

Research Areas:  

Inflammation/Immunology

MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
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Antifibrotic agent 1
Antifibrotic agent 1
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Cat. No.: HY-176194
Target:  

Collagen c-Fms PDGFR Src

Research Areas:  

Inflammation/Immunology

Antifibrotic agent 1 is an orally active anti-idiopathic pulmonary fibrosis (IPF) agent. Antifibrotic agent 1 effectively attenuates IPF-related processes, including TGF-β induced EMT and FMT processes, as well as pro-fibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α and Src family kinases (SFKs), while sparing VEGFRs, FGFRs and Abl to minimize off-target toxicity. Antifibrotic agent 1 has potent anti-fibrotic activity in Bleomycin (BLM) (HY-108345)-induced pulmonary fibrosis mice model .
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TM5007
TM5007
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Cat. No.: HY-119160
CAS No.: 342595-05-5
Target:  

PAI-1

Research Areas:  

Inflammation/Immunology Cancer

TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung .
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5-HT2B antagonist-2
5-HT2B antagonist-2
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Cat. No.: HY-172258
Target:  

5-HT Receptor

Research Areas:  

Cancer

5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases .
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Regiafuran C
Regiafuran C
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Cat. No.: HY-N17639
CAS No.: 2059921-60-5
Category:  

Moraceae Extract Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

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