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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
flight tunnel
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "flight tunnel" in MCE Product Catalog:
629
629 Publications Verification
Research Areas:
Y-27632 is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .
629
629 Publications Verification
Cat. No.: HY-10071A
CAS No.: 331752-47-7
Research Areas:
Y-27632 hydrochloride hydrate is a ROCK inhibitor with Ki values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 hydrochloride hydrate exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 hydrochloride hydrate enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 hydrochloride hydrate induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 hydrochloride hydrate promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .
14
14 Cited Publications
Synonyms: α-Cyano-4-hydroxycinnamate
Target:
Research Areas:
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications .
1
1 Cited Publications
Cat. No.: HY-W027446
CAS No.: 65-22-5
Target:
1
Category:
Human Gut Microbiota Metabolites Natural Products Microorganism Endogenous metabolite Disease Research Fields Cancer
Target:
1
1
1 Cited Publications
Cat. No.: HY-P73580
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TTR; Transthyretin; PALB; CTS1; HsT2651; CTS; Prealbumin, Amyloidosis Type I; ATTR; TBPA; Epididymis Luminal Protein 111; Thyroxine-Binding Prealbumin; Carpal tunnel Syndrome 1; TTR Protein; Prealbumin; AMYLD1; HEL111; TTN
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P3570
CAS No.: 98968-94-6
Synonyms: Lom-AKH-II
Target:
Research Areas:
SHP2-IN-13 is a highly selective and orally active SHP2 “tunnel site” allosteric inhibitor with an IC50 of 83.0 nM. SHP2-IN-13 has the potential for cancers bearing RTK oncogenic drivers and SHP2-related diseases research.
Cat. No.: HY-P3572
CAS No.: 61627-67-6
Synonyms: Lom-AKH-I
Target:
Research Areas:
Cat. No.: HY-115527
CAS No.: 902891-37-6
SHP244 is a conformational inhibitor targeting the "latch allosteric site" (site 2) of the SHP2 protein with an IC50 value for SHP2 WT of 60 μM. SHP244 has no significant effect on the level of p-ERK alone. SHP244 combined with RMC-4550 (HY-116009) ("tunnel site" site 1 inhibitor) can reduce p-ERK and inhibit the rebound of p-ERK, thereby reducing drug resistance. SHP244 can be used to study drug resistance in FGFR-driven cancers .
Cat. No.: HY-W042284
CAS No.: 638-59-5
Synonyms: Myristyl acetate
Target:
Cat. No.: HY-157469
Synonyms: NPD3064
TNT-i (NPD3064) is an inhibitor targeting M-Sec. TNT-i inhibits M-Sec-induced tunneling nanotube (TNT) formation reversibly. TNT-i reduces wild-type HIV-1 production in macrophages and M-Sec-expressing T cells. TNT-i shows low cytotoxic effects on macrophages and T cells. TNT-i can be used for the research of HIV-1 infection .
Cat. No.: HY-165127
CAS No.: 20197-09-5
Synonyms: (+)-Octopinic acid
Octopinic acid ((+)-Octopinic acid) is a biomarker (opine) for plant crown gall or hairy root disease detected by ultra-performance liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry with activity useful for disease diagnosis and analysis.
Cat. No.: HY-166051
CAS No.: 68820-32-6
Synonyms: Z4-11Al; (Z)-4-Undecenal
Target:
Research Areas:
4 (Z)-Undecenal (Z4-11Al; (Z)-4-Undecenal) is a volatile aldehyde sex pheromone produced by female Drosophila melanogaster, acting as an agonist to activate the Drosophila olfactory receptor Or69aB and eliciting flight attraction and courtship behavior in Drosophila. 4 (Z)-Undecenal also activates human OR2W1, binding to its binding site through hydrophobic interactions and hydrogen bonds. 4 (Z)-Undecenal can be used in research related to olfactory receptors and insect pheromones .
Cat. No.: HY-W778833
CAS No.: 62972-93-4
Category:
Target:
Cat. No.: HY-183782
Target:
Research Areas:
SA1103064 is a potent antibiotic with antibacterial activity against multiple resistant bacterial strains. SA1103064 binds to the bacterial ribosome's nascent peptide exit tunnel. SA1103064 can be used for the research of bacterial infections .
Cat. No.: HY-183936
SDUY127 is a bivalent SHP2 inhibitor with an IC50 value of 16 nM. SDUY127 binds simultaneously to the tunnel allosteric site and latch allosteric site of SHP2 at a 1:1 stoichiometric ratio, stabilizes the protein in an inactive conformation, and induces sustained inhibition of the MAPK signaling pathway. SDUY127 can be used in research related to leukemia and hepatocellular carcinoma .
Cat. No.: HY-189684
Target:
Research Areas:
CETP-IN-5 is a CETP inhibitor with an IC50 of 75.54 nM. CETP-IN-5 is predicted by computer simulation to bind the central hydrophobic tunnel and restrict the lipid transfer pathway, thereby inhibiting neutral lipid transfer. CETP-IN-5 shows an inhibitory effect that increases with increasing N-alkyl ester chain length, with the longest-chain N-alkyl ester exhibiting the highest activity. CETP-IN-5 can be used for research on cardiovascular diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
