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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
frameshift mutagenesis
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "frameshift mutagenesis" in MCE Product Catalog:
1
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VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors .
1
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria .
Category:
Natural Products Immune System Disorder Other Diseases Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields
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Cat. No.: HY-W755252
CAS No.: 3817-11-6
Synonyms: BBN
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N-Butyl-N-(4-hydroxybutyl)nitrosamine is a potent mutagen that can cause high-level of mutagenesis specifically in the epithelial cells (urothelial) of the urinary bladder. N-Butyl-N-(4-hydroxybutyl)nitrosamine is used to induce bladder cancer in rodents .
Category:
Plant Anacardiaceae Extract Toxicodendron vernicifluum (Stokes) F. A. Barkl. Extract Phenols Polyphenols Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-E70056
CAS No.: 71124-51-1
Synonyms: PmST1(M144D)
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α2,3-Sialyltransferase, Pasteurella multocida (P-1059) (PmST1(M144D)), a sialyltransferase, can be isolated from Pasteurella multocida. alpha-2,3-Sialyltransferase (PmST1) can be converted into regioselective α2-6-sialyltransferase by saturation mutagenesis and regioselective screening .
Cat. No.: HY-135805B
Purity: 96.58%
(Rac)-JBJ-04-125-02 acetate is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, selective mutagenesis, allosteric and orally active EGFR inhibitor .
Cat. No.: HY-161242A
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CBI1 formic is a covalent BAX inhibitor. CBI1 formic selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex .
Cat. No.: HY-W127746
CAS No.: 550-74-3
Research Areas:
Picrolonic acid is a nematode hatching agent and bacterial frameshift mutagen. Picrolonic acid induces egg hatching in various nematodes. Picrolonic acid induces frameshift mutations in Salmonella. Picrolonic acid preferentially inhibits the growth of DNA polymerase-deficient E. coli . Picrolonic acid also serves as an analytical reagent for the determination of calcium, magnesium, lead, strontium, and thorium, and for the analysis of alkaloids, tryptophan, and phenylalanine. Picrolonic acid is used in research related to bacterial and parasitic infections .
Cat. No.: HY-W016433
CAS No.: 153-78-6
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2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .
Cat. No.: HY-W016433S1
CAS No.: 347841-44-5
Cat. No.: HY-W016433R
CAS No.: 153-78-6
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2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .
Cat. No.: HY-N5054
CAS No.: 1277188-85-8
Category:
Plant Flavonoids Flavonones Other Families Extract Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-W587784
CAS No.: 542-40-5
Cat. No.: HY-W728005
CAS No.: 1225177-95-6
Covidcil-19 (compound C5) avidly binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with a Kd of 11 nM. Covidcil-19 stabilizes the hairpin’s folded state and impairs frameshifting in cells. Covidcil-19 reduces frameshifting efficiency of the SARS-CoV-2 FSE and does not affect SARS-CoV-2 FSE RNA levels. Covidcil-19 inhibits a process essential for SARS-CoV-2 viral propagation .
Cat. No.: HY-157848
CAS No.: 924058-34-4
SARS-CoV-2-IN-82 (compound A) is a Programmed-1 ribosomal frameshift (-1 PRF) inhibitor of SARS-CoV-2 .
Cat. No.: HY-161242
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Research Areas:
CBI1 is a covalent BAX inhibitor. CBI1 selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 blocks t-2-hex lipidation and oligomerization of BAX. CBI1 inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex .
Category:
Plant Anacardiaceae Extract Toxicodendron vernicifluum (Stokes) F. A. Barkl. Extract Phenols Polyphenols
Target:
Cat. No.: HY-113338A
CAS No.: 1246818-54-1
Synonyms: 8-Oxoguanine hydrochloride; 8-oxo-Gua hydrochloride
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8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
