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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
165 Results for "
heart rate
" in MedChemExpress (MCE) Product Catalog:
Products (165)
165 Results for "heart rate" in MCE Product Catalog:
10
10 Publications Verification
Cat. No.: HY-P0203
CAS No.: 83651-90-5
Synonyms: CGRP (83-119), mouse, rat
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
10
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Cardiovascular Disease Metabolic Disease Inflammation/Immunology
6
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Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor . Antianginal agent.
6
6 Cited Publications
Cat. No.: HY-17401
CAS No.: 95635-56-6
Synonyms: CVT 303 dihydrochloride; RS 43285
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Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .
4
4 Cited Publications
Cat. No.: HY-B0162A
CAS No.: 148849-67-6
Target:
Research Areas:
Cardiovascular Disease Infection Neurological Disease Metabolic Disease Cancer
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .
4
4 Cited Publications
Cat. No.: HY-B0162
CAS No.: 155974-00-8
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Research Areas:
Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .
3
Category:
Cardiovascular Disease Alkaloids Plants Disease Research Fields Indole Alkaloids Apocynaceae Extract Catharanthus roseus (L.) G. Don
Target:
3
3 Cited Publications
Synonyms: (+)-3,4-Didehydrocoronaridine Tartrate
Category:
Cardiovascular Disease Alkaloids Plants Disease Research Fields Cancer Indole Alkaloids Apocynaceae Extract Catharanthus roseus (L.) G. Don
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2
2 Cited Publications
Synonyms: SR35021 hydrochloride
Research Areas:
Debutyldronedarone hydrochloride (SR35021 hydrochloride) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone hydrochloride inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone hydrochloride reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone hydrochloride can be used in studies related to ventricular fibrillation and atrial fibrillation .
1
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1
1 Cited Publications
Cat. No.: HY-P1604
CAS No.: 60748-45-0
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1
1 Cited Publications
Cat. No.: HY-P1604A
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Cat. No.: HY-A0154
CAS No.: 17598-65-1
Synonyms: Deacetyllanatoside C; Desacetyllanatoside C
Category:
Cardiovascular Disease Digitalis purpurea Linn. Cardiacglycosides Scrophulariaceae Extract Plants Disease Research Fields Steroids
Target:
Synonyms: Corwin hemifumarate; ICI 118587 hemifumarate
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Xamoterol (Corwin; ICI 118587) hemifumarate is an orally active and selective β1-adrenoceptor partial agonist. Xamoterol hemifumarate acts as agonist at low sympathetic tone, antagonist at high sympathetic tone, with context-dependent cardiovascular effects including modulated heart rate, blood pressure, and cardiac output. Xamoterol hemifumarate can be used for the research of heart failure, postural hypotension, and ischemic heart disease .
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Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .
Cat. No.: HY-17611
CAS No.: 1593673-23-4
Synonyms: MSP-2017; (-)-MSP-2017
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Research Areas:
Etripamil (MSP-2017) is a short-acting, L-type calcium-channel antagonist. Etripamil inhibits calcium influx through slow calcium channels, thereby slowing AV node conduction and prolonging the AV node refractory period. Etripamil increases heart rate and decreases systolic blood pressure. Etripamil can be used in the study of paroxysmal supraventricular tachycardia (PSVT) .
Synonyms: KHK-IN-3
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation .
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Clobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research .
Cat. No.: HY-B0162AS
CAS No.: 2070009-63-9
Cat. No.: HY-19259
CAS No.: 186393-42-0
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Research Areas:
GP3269 is a selective and orally active human adenosine kinase (AK) inhibitor with an IC50 of 11 nM against human adenosine kinase. GP3269 increases adenosine levels at epileptic foci, activates A1 receptors on excitatory neurons, and exhibits anticonvulsant activity in rats. GP3269 does not induce hemodynamic effects including changes in blood pressure or heart rate in rats. GP3269 can be used for epilepsy-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
