Plantaginaceae Extract

Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. Digitonin is an natural detergent.

Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects.

Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

Isolugrandoside is a nature product. Isolugrandoside can be isolated from Digitalis davisiana Heywood.

Acetyldigitoxin (Digitoxin 3'''-Acetate) is a cardiac glycoside. Acetyldigitoxin can come from the leaves of Digitalis species. Acetyldigitoxin reduces the heart rate and can be used for cardiac failure rasearch.

Digitoxose (D-(+)-Digitoxose) is a 2,6-dideoxy-D-ribo-hexose and the dideoxysugar moiety of Digitoxin (HY-B1357) and Digoxin (HY-B1049). Digitoxose acts by competitively inhibiting D-Glucose (HY-B0389)-stimulated Insulin (HY-P0035) release from pancreatic islets and shifting the glucose dose-response curve to the right. Digitoxose can be used in research on non-insulin-dependent diabetes mellitus.

Lanatoside B is an anticancer agent. Lanatoside B can be isolated from the leaves of Digitalis lanata. Lanatoside B exhibits anticancer activity against cholangiocarcinoma.

Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na⁺/K⁺-ATPase inhibitor, with an IC₅₀ of 1.18e-6 M against the porcine high-affinity subtype and an IC₅₀ of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure.

Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes.

Glucodigifucoside, a cardenolide glycoside that could be isolated from the seeds of Digitalis purpurea, exhibits potent cytotoxicity against human renal adenocarcinoma cell line ACHN.

Digitoxin (Standard) is the analytical standard of Digitoxin. This product is intended for research and analytical applications. Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

Phomarin is an inhibitor for dihydrofolate reductase (DHFR). Phomarin exhibits activity against Plasmodium parasites and fungi including Mycrobotryum violaceum and Botrytis cinerea. Phomarin can be used for the research of malaria and fungal infections.

Odoroside H is a natural cardenolide with anticancer activities.

Digitalin (Digitalinum verum) is a cardiac glycoside and can be isolated from Digitalis.

Kutkoside is an orally active iridoid glycoside mixture composed of picroside II, picroside IV, and 6-ferulloylcatalpol. Kutkoside exerts antioxidant effects by targeting hepatic and lysosomal enzymes, inhibiting Xanthine Oxidase (IC₅₀ = 354.6 μM) and lipid peroxidation, and downregulates MMP-1/2/9/13 to suppress tumor invasion and inflammatory mediators. Kutkoside can be used in research on D-galactosamine-induced liver injury and breast cancer.

Stachannin A is a 6-hydroxy-flavone glucoside that can be found in Paederota lutea.

Epimeridinoside A is a phenylethanoid glucoside with an α-L-rhamnosyl-(1→2)-β-D-glucose structure that can be found in Plantago depressa Willd.

Plantago asiatica polysaccharide is a polysaccharide derived from Plantago asiatica.

Plantaginis semen polysaccharide is a polysaccharide derived from Plantaginis semen.