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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
high-affinity binding sites
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "high-affinity binding sites" in MCE Product Catalog:
5
5 Cited Publications
Target:
Research Areas:
RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites .
5
5 Cited Publications
Target:
Research Areas:
RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites .
4
4 Cited Publications
Synonyms: JNJ-42847922
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Research Areas:
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
4
4 Cited Publications
Synonyms: JNJ-42847922 hydrochloride
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Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
3
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3
3 Cited Publications
Cat. No.: HY-P0185
CAS No.: 189388-22-5
Category:
Natural Products Monophenols Pyrrole Alkaloids Neurological Disease Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids
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3
3 Cited Publications
Cat. No.: HY-P0185A
CAS No.: 1276123-71-7
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1
1 Cited Publications
WDR5-IN-5 is an orally active and selective inhibitor of WIN site of WD repeat domain 5 (WDR5). WDR5-IN-5 exhibits anti-proliferative activity towards cancer cells and good pharmacokinetics profile in mice. WDR5-IN-5 shows high affinity to WDR5 and the binding affinity Ki value <0.02 nM .
Cat. No.: HY-P99009
CAS No.: 2187430-05-1
Synonyms: RVT-1401; HBM9161; IMVT-1401
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Cat. No.: HY-18698
CAS No.: 142326-59-8
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L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity .
Synonyms: Mepirodipine hydrochloride; YM-09730-5
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Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [ 3H] initrendipine binding sites (Ki = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance .
Synonyms: trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA
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(E)-4-Hydroxycrotonic acid (trans-4-Hydroxycrotonic acid) is a semirigid linear analog of γ-Hydroxybutyric acid. (E)-4-Hydroxycrotonic acid can be present in the mammalian central nervous system. (E)-4-Hydroxycrotonic acid binds to high-affinity γ-Hydroxybutyric acid binding sites and displaces radioligands .
Cat. No.: HY-P0186A
CAS No.: 1276124-00-5
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Cat. No.: HY-107322A
CAS No.: 104713-75-9
Synonyms: Mepirodipine; YM-09730-5 Free base
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Research Areas:
Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [ 3H] initrendipine binding sites (Ki = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance .
Synonyms: EMD 57445
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Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent .
Cat. No.: HY-P1076A
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Cat. No.: HY-15419R
CAS No.: 199864-86-3
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RS-127445 (hydrochloride) (Standard) is the analytical standard of RS-127445 (hydrochloride). This product is intended for research and analytical applications. RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites .
Synonyms: Mepirodipine-d5 hydrochloride; YM-09730-5-d5 hydrochloride
Synonyms: Mepirodipine-d5; YM-09730-5-d5 Free base
Cat. No.: HY-P11131
Synonyms: Human lactoferrin (28-34)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
