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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
285 Results for "
histone-H3
" in MedChemExpress (MCE) Product Catalog:
Products (285)
285 Results for "histone-H3" in MCE Product Catalog:
61
61 Publications Verification
Cat. No.: HY-123606
CAS No.: 1652629-23-6
Target:
Research Areas:
GSK484 is a PAD4 inhibitor that effectively inhibits protein citrullination and the formation of neutrophil extracellular traps (NETs) by blocking the catalytic activity of PAD4. GSK484 suppresses the production of histone H3, MHC-I expression, CD8 + T cell activation, proliferation and inflammatory cytokine release. GSK484 reduces inflammation and bone destruction in collagen-induced rheumatoid arthritis, alleviates pain and mast cell activation in sickle cell disease, and improves myocardial ischemia-reperfusion injury and experimental colitis. In addition, GSK484 restores intestinal microbial homeostasis by reversing ferroptosis-induced dysbiosis. GSK484 can be used to study the disease mechanisms of rheumatoid arthritis, sickle cell disease, thrombosis, myocardial injury, colitis and other conditions [3] .
16
16 Cited Publications
Cat. No.: HY-16993
CAS No.: 1801787-56-3
OICR-9429, a chemical probe, is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) .
15
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases [3].
14
Target:
Research Areas:
CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF-κB and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis .
13
13 Cited Publications
Research Areas:
EPZ020411 is a selective, blood-brain barrier-permeable PRMT6 inhibitor with an IC50 of 0.010 μM. EPZ020411 blocks PRMT6-mediated histone H3R2 methylation, reduces ROS production, and inhibits Apoptosis. EPZ020411 is applicable to research related to neuropathic pain, colorectal cancer, ototoxicity, hearing loss and glioblastoma [3] .
13
13 Cited Publications
Research Areas:
EPZ020411 hydrochloride is a selective, blood-brain barrier-permeable PRMT6 inhibitor with an IC50 of 0.010 μM. EPZ020411 hydrochloride blocks PRMT6-mediated histone H3R2 methylation, reduces ROS production, and inhibits Apoptosis. EPZ020411 hydrochloride is applicable to research related to neuropathic pain, colorectal cancer, ototoxicity, hearing loss and glioblastoma [3] .
8
8 Cited Publications
Target:
Research Areas:
CHR-6494 is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR-6494 inhibits histone H3T3 phosphorylation. CHR-6494 can be used in the research of cancer .
6
6 Cited Publications
Target:
Research Areas:
SETDB1-TTD-IN-1 is a SETDB1 methyltransferase activator and SETDB1-TTD competitive inhibitor (Kd of 88 nM), and selectivity for SETDB1-TTD over other tudor and bromodomain proteins. SETDB1-TTD-IN-1 stimulates methyltransferase activity via increased catalytic activity, promotes Akt1 Lys64 methylation, Akt1 Thr308 phosphorylation and activation. SETDB1-TTD-IN-1 prevents SETDB1-TTD-histone H3 peptide association, induces global gene expression changes, exhibits cellular target engagement, and acts as a tool compound for SETDB1-TTD function exploration. SETDB1-TTD-IN-1 can be used for the research of breast cancer .
5
5 Cited Publications
Cat. No.: HY-16705
CAS No.: 1374601-40-7
Target:
Research Areas:
BRD4770 is a histone methyltransferase G9a inhibitor. BRD4770 reduces di- and trimethylation of lysine 9 on histone H3 (H3K9) with an EC50 of 5 μM, and has less or little effect toward H3K27me3, H3K36me3, H3K4me3, and H3K79me3. BRD4770 can activate the ataxia telangiectasia mutated (ATM) pathway and induce cell senescence .
3
3 Cited Publications
Cat. No.: HY-W013274
CAS No.: 357649-93-5
Target:
Research Areas:
CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B) .
2
2 Cited Publications
Cat. No.: HY-P80167
Synonyms: H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, HIST1H3C, H3FC, H3C1, histone H3.1, histone H3/a, histone H3/b, histone H3/c, histone H3/d, histone H3/f, histone H3/h, histone H3/i, histone H3/j, histone H3/k, histone H3/l
2
2 Cited Publications
Cat. No.: HY-P80169
Synonyms: H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, HIST1H3C, H3FC, H3C1, histone H3.1, histone H3/a, histone H3/b, histone H3/c, histone H3/d, histone H3/f, histone H3/h, histone H3/i, histone H3/j, histone H3/k, histone H3/l
2
2 Cited Publications
Cat. No.: HY-P80922
Synonyms: H3FA; HIST1H3A; H3C2; H3FL; HIST1H3B; H3C3; H3FC HIST1H3C; H3C4; H3FB; HIST1H3D; H3C6; H3FD; HIST1H3E; H3C7; H3FI; HIST1H3F; H3C8; H3FH; HIST1H3G; H3C10; H3FK; HIST1H3H; H3C11; H3FF; HIST1H3I; H3C12; H3FJ; HIST1H3J; HIST1H3C; H3FC; H3C1; histone H3.1; histone H3/a; histone H3/b; histone H3/c; histone H3/d; histone H3/f; histone H3/h; histone H3/i; histone H3/j; histone H3/k; histone H3/l
2
2 Cited Publications
Cat. No.: HY-P86672
Synonyms: H3C15; H3C14; H3C13; HIST2H3A; H3F2; H3FM; HIST2H3C; HIST2H3D; histone H3.2; H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; histone H3/m; histone H3/o
2
1
1
1 Cited Publications
Cat. No.: HY-P80176
Synonyms: H3K9me3; H3 histone family member E pseudogene; H3 histone family, memberA; H3/A; H31_HUMAN; H3F3; H3FA; Hist1H3a; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; histone 1, H3a; histone cluster 1, H3a; histone H3 3 pseudogene; histone H3.1; histone H3/a; histone H3/b; histone H3/c; histone H3/d; histone H3/f; histone H3/h; histone H3/i; histone H3/j; histone H3/k; histoneH3/l; H3K9me2; histoneH3(trimethylK9)
1
1 Cited Publications
Cat. No.: HY-P80530
Synonyms: H3FA; HIST1H3A; H3C2; H3FL; HIST1H3B; H3C3; H3FC HIST1H3C; H3C4; H3FB; HIST1H3D; H3C6; H3FD; HIST1H3E; H3C7; H3FI; HIST1H3F; H3C8; H3FH; HIST1H3G; H3C10; H3FK; HIST1H3H; H3C11; H3FF; HIST1H3I; H3C12; H3FJ; HIST1H3J; HIST1H3C; H3FC; H3C1; histone H3.1; histone H3/a; histone H3/b; histone H3/c; histone H3/d; histone H3/f; histone H3/h; histone H3/i; histone H3/j; histone H3/k; histone H3/l
1
1 Cited Publications
Cat. No.: HY-P72332
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: H3C1; histone H3/C; Prev. HIST1H3A; HIST1H3J; Prev. H3FA; HIST1H3I; H3/A; HIST1H3H; histone Cluster 1 H3 Family Member A; HIST1H3G; H3 histone Family, Member A; HIST1H3F; histone Cluster 1, H3a; HIST1H3E; histone 1, H3a; HIST1H3D; histone H3.1; HIST1H3B;
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
