Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
human 12-LOX
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "human 12-LOX" in MCE Product Catalog:
4
4 Cited Publications
Target:
Research Areas:
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .
1
1 Cited Publications
Cat. No.: HY-P72076
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ALOX12; Platelet 12-LOX; Arachidonate 12-Lipoxygenase, 12S Type; LOG12; 12S-LOX; Arachidonate 15-Lipoxygenase,15S-Type; Polyunsaturated Fatty Acid Lipoxygenase ALOX12; Platelet-Type 12-Lipoxygenase; Arachidonate 12-Lipoxygenase, 12S-Type; Arachidonate 12-Lipoxygenase; Arachidonate (12S)-Lipoxygenase; Linoleate (13S)-Lipoxygenase; Arachidonate (15S)-Lipoxygenase; Linoleate 13S-Lipoxygenase; Platelet-Type Lipoxygenase 12; 12-LOX; Lipoxin Synthase 12-LO; 12LO; 12S-Lipoxygenase
Species:
Human
Source:
E. coli
Cat. No.: HY-W089800
CAS No.: 18829-56-6
Synonyms: trans-2-Nonen-1-al
Target:
Research Areas:
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .
Cat. No.: HY-111310R
CAS No.: 847163-28-4
Target:
Research Areas:
ML351 (Standard) is the analytical standard of ML351 (HY-111310). This product is intended for research and analytical applications. ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
