44

Brequinar

44 Publications Verification

Cat. No.: HY-108325

CAS No.: 96187-53-0

Purity: 99.89%

Synonyms: DUP785; NSC 368390

Target:

Dihydroorotate Dehydrogenase SARS-CoV Virus Protease DNA/RNA Synthesis

Research Areas:

Infection Inflammation/Immunology Cancer

Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC₅₀ of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.

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5

Tenovin-6

5 Cited Publications

Cat. No.: HY-15510

CAS No.: 1011557-82-6

Purity: 98.00%

Target:

MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy

Research Areas:

Cancer

Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH) .

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5

Tenovin-6 Hydrochloride

5 Cited Publications

Cat. No.: HY-15510B

CAS No.: 1011301-29-3

Purity: 98.88%

Target:

MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy

Research Areas:

Cancer

Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC₅₀s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH) .

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4

Farudodstat

4 Cited Publications

Cat. No.: HY-129239

CAS No.: 1035688-66-4

Purity: 99.68%

Synonyms: ASLAN003

Target:

Dihydroorotate Dehydrogenase DNA/RNA Synthesis Apoptosis

Research Areas:

Cancer

Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC₅₀ of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice .

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2

ML390

2 Cited Publications

Cat. No.: HY-100688

CAS No.: 2029049-79-2

Purity: 99.72%

Target:

Dihydroorotate Dehydrogenase

Research Areas:

Cancer

ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models .

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JNJ-74856665

Cat. No.: HY-139189

CAS No.: 2511248-11-4

Purity: 99.74%

Synonyms: DHODH-IN-16; JNJ-6665

Target:

Dihydroorotate Dehydrogenase DNA/RNA Synthesis

Research Areas:

Cancer

JNJ-74856665 (DHODH-IN-16) is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 0.396 nM for human DHODH .

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hDHODH-IN-4

Cat. No.: HY-128787

CAS No.: 1644156-56-8

Purity: 99.73%

Target:

Dihydroorotate Dehydrogenase DNA/RNA Synthesis Influenza Virus

Research Areas:

Infection

hDHODH-IN-4 is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor, with a pIC₅₀ of 7.8 for human recombinant DHODH. hDHODH-IN-4 inhibits measles virus replication, with a pMIC₅₀ of 8.8 .

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