8 Results for "

human Fyn

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "human Fyn" in MCE Product Catalog:

5
Curcumenol
Curcumenol
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5 Cited Publications
Cat. No.: HY-N2259
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol
Category:  

Plant Curcuma phaeocaulis Valeton Extract Neurological Disease Zingiberaceae Extract Terpenoids Sesquiterpenes Disease Research Fields Inflammation/Immunology Cancer

Target:  

Cytochrome P450 NF-κB MMP Interleukin Related TNF Receptor Akt p38 MAPK Ferroptosis Apoptosis CXCR COX Caspase Bcl-2 Family TGF-β Receptor

Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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FYN Human Pre-designed siRNA Set A
FYN Human Pre-designed siRNA Set A
Cat. No.: HY-RS05174
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

FYN Human Pre-designed siRNA Set A contains three designed siRNAs for FYN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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FYN Y531F Recombinant Human Active Protein Kinase
FYN Y531F Recombinant Human Active Protein Kinase
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Cat. No.: HY-E70726
Target:  

Src

Research Areas:  

Cancer

FYN Y531F Recombinant Human Active Protein Kinase is an oncogene that directly activated YANK2 through phosphorylation its Y110, and Fyn-mediated YANK2 phosphorylation at Y110 site promotes glioma growth by increasing its stability .
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Curcumenol (Standard)
Curcumenol (Standard)
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Cat. No.: HY-N2259R
CAS No.: 19431-84-6
Synonyms: (+)-Curcumenol (Standard)
Category:  

Plant Curcuma phaeocaulis Valeton Extract Zingiberaceae Extract Terpenoids Sesquiterpenes

Target:  

Reference Standards Cytochrome P450 NF-κB MMP Interleukin Related TNF Receptor Akt p38 MAPK Ferroptosis Apoptosis CXCR COX Caspase Bcl-2 Family TGF-β Receptor

Curcumenol (Standard) ((+)-Curcumenol (Standard)) is the analytical standard of Curcumenol (HY-N2259). This product is intended for research and analytical applications. Curcumenol ((+)-Curcumenol) is a natural compound with oral efficacy, exhibiting an IC50 of 12.6 μM and a Ki of 10.8 μM against human CYP3A4. Curcumenol inhibits TNFα-induced phosphorylation/degradation of IκBα, phosphorylation/nuclear translocation of NF-κB p65, as well as the upregulation of MMP3, MMP9, MMP13, TRAF3, IL1RL1, TNFα and IL-1β. Curcumenol suppresses LPS-induced phosphorylation of Akt and p38 MAPK, as well as the production of pro-inflammatory mediators/proteins, and downregulates the SLC7A11/NF-κB/TGF-β pathway. Curcumenol binds to and inhibits the activation of Fyn and Lyn, blocks the function of downstream FcεRI signaling components, and reduces the release of allergic mediators/cytokines. Curcumenol upregulates the expression of KDM6B, and promotes chondrocyte proliferation and cartilage repair. Curcumenol induces ferroptosis and apoptosis, regulates the EMT process, and inhibits tumor growth and metastasis of triple-negative breast cancer. Curcumenol possesses anti-inflammatory, neuroprotective, antioxidant, antitumor, antiviral and hepatoprotective activities. Curcumenol can be used in research related to intervertebral disc degeneration, cancer, inflammation, central nervous system neurodegenerative diseases, allergic reactions and knee osteoarthritis .
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FRK Recombinant Human Active Protein Kinase
FRK Recombinant Human Active Protein Kinase
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Cat. No.: HY-E70725
Target:  

Src

Research Areas:  

Cancer

FRK Recombinant Human Active Protein Kinase, a non-receptor tyrosine kinase Fyn-related kinase, is a member of the BRK family kinases (BFKs). FRK may be involved in tumor progression .
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FYN Protein, Human (Active, Biotinylated, sf9, His, Flag, Avi)
FYN Protein, Human (Active, Biotinylated, sf9, His, Flag, Avi)
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Cat. No.: HY-P702727
Purity:  ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Fyn; MGC45350; Fyn Proto-Oncogene, Src Family Tyrosine Kinase; P59-Fyn; SLK; OKT3-Induced Calcium Influx Regulator; Tyrosine-Protein Kinase Fyn; Tyrosine Kinase P59Fyn(T); Proto-Oncogene C-Fyn; Src/Yes-Related Novel; SYN; C-Syn Protooncogene; Fyn Oncogene
Species:  
Human
Source:  
Sf9 insect cells
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Tyrosine kinase-IN-12
Tyrosine kinase-IN-12
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Cat. No.: HY-187803
Target:  

VEGFR Bcr-Abl Src

Research Areas:  

Others

Tyrosine kinase-IN-12 is a selective kinase inhibitor with inhibitory activity against human tyrosine kinases KDR, Abl, Lyn and Fyn .
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FRK Protein, Human (Active, sf9, GST)
FRK Protein, Human (Active, sf9, GST)
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Cat. No.: HY-P705576
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FRK; PTK5 Protein Tyrosine Kinase 5; Prev. PTK5; Protein-Tyrosine Kinase 5; RAK; Fyn-Related Kinase; GTK; Fyn-Related Src Family Tyrosine Kinase; Nuclear Tyrosine Protein Kinase RAK; Fyn-Related Kinase; Fyn Related Src Family Tyrosine Kinase; Tyrosine-Pro
Species:  
Human
Source:  
Sf9 insect cells
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