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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
human MetAP-2
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "human MetAP-2" in MCE Product Catalog:
Cat. No.: HY-RS08350
Target:
Research Areas:
METAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for METAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P70364
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MetAP2; MAP2; Methionyl Aminopeptidase 2; MetAP 2; MNPEP; MAP 2; P67; Testicular Tissue Protein Li 17; Initiation Factor 2-Associated 67 KDa Glycoprotein; EIF-2-Associated P67 Homolog; Methionine Aminopeptidase 2; Alternative Protein MetAP2; Peptidase M;
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703925
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MetAP2; MAP2; Methionyl Aminopeptidase 2; MetAP 2; MNPEP; MAP 2; P67; Testicular Tissue Protein Li 17; Initiation Factor 2-Associated 67 KDa Glycoprotein; EIF-2-Associated P67 Homolog; Methionine Aminopeptidase 2; Alternative Protein MetAP2; Peptidase M;
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-182419
CAS No.: 904680-01-9
A-849519 is a reversible methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 19 nM. A-849519 binds to the active site of the Mn 2+ form of human MetAP-2, where the oxygen atom of one acidic functional group interacts with the manganese ion, and another heteroatom binds to the water molecule above the two manganese ions, thereby functionally inhibiting enzyme activity. A-849519 inhibits the methionine processing activity of MetAP-2 as well as the proliferation of fibrosarcoma cells. A-849519 can be used in studies related to fibrosarcoma .
Cat. No.: HY-183876
CAS No.: 661482-39-9
Target:
Research Areas:
LAF-153 is a Methionine Aminopeptidase-2 (MetAP-2) inhibitor with human IC50 values of 0.074 μM and 0.16 μM.LAF-153 has a t-butyl group extending into the innermost portion of the MetAP-2 cleft, a lactam ring coordinated in the enzyme’s shallow surface pocket, and three hydroxyl groups coordinating to the two cobalt ions in the enzyme’s active site .
Cat. No.: HY-133806
CAS No.: 912569-37-0
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC50 of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
