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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
human PAK1
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "human PAK1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P71530
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PAK1; Alpha-PAK; P21 (RAC1) Activated Kinase 1; P65-PAK; P21/Cdc42/Rac1-Activated Kinase 1 (STE20 Homolog, Yeast); Non-Specific Serine/Threonine Protein Kinase; P21/Cdc42/Rac1-Activated Kinase 1 (Yeast Ste20-Related); P21-Activated Kinase 1; P21 Protein (
Species:
Human
Source:
E. coli
Cat. No.: HY-RS09983
Target:
Research Areas:
PAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-148821
CAS No.: 3009849-06-0
BJG-05-039 is an inhibitor targeting PAK1, with an IC50 of 233 nM against human PAK1. BJG-05-039 induces the selective degradation of PAK1 and inhibits its kinase activity by conjugating NVS-PAK1-1 (HY-100519) with Lenalidomide (HY-A0003) to recruit Cereblon. BJG-05-039 can be used in research related to breast cancer and ovarian cancer .
Cat. No.: HY-164374
CAS No.: 445007-59-0
AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways .
Cat. No.: HY-RS09986
Target:
Research Areas:
PAK1IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAK1IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-187370
Target:
Research Areas:
YDH-704 is a PAK1/HDAC10 inhibitor, with IC50 values of 0.05 μM and 0.02 μM against human targets, respectively. YDH-704 blocks PAK1-mediated oncogenic signaling pathways, inhibits the proliferation and migration of tumor cells, suppresses the epigenetic regulatory function of HDAC10, downregulates PD-L1 expression, and regulates polyamine metabolism. YDH-704 reduces MDSC/Treg infiltration, enhances the infiltration and activation of CD8 + T cells, and inhibits tumor growth and lung metastasis. YDH-704 can be used for research on triple-negative breast cancer .
Cat. No.: HY-184447
CAS No.: 3091508-49-2
RN193 is a type II kinase inhibitor with a human PAK1 IC50 of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1, PAK2, and PAK3, and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1, GSK3B, ULK1, MELK, MAPK13, BRAF, and STK10, indicating binding and stabilization of these proteins. RN193 induces formation of PAK3:PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states .
Cat. No.: HY-P702648
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PKN1; Protein Kinase PKN-Alpha; Prev. PRKCL1; PAK-1; PAK1; Non-Specific Serine/Threonine Protein Kinase; PRK1; Serine/Threonine Protein Kinase N; PKN; Protein Kinase C-Related Kinase 1; Protein Kinase C-Like 1; Protein-Kinase C-Related Kinase 1; DBK; Seri
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705857
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PKN1; Protein Kinase PKN-Alpha; Prev. PRKCL1; PAK-1; PAK1; Non-Specific Serine/Threonine Protein Kinase; PRK1; Serine/Threonine Protein Kinase N; PKN; Protein Kinase C-Related Kinase 1; Protein Kinase C-Like 1; Protein-Kinase C-Related Kinase 1; DBK; Seri
Species:
Human
Source:
sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
