Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
human dendritic cells
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "human dendritic cells" in MCE Product Catalog:
19
19 Publications Verification
Cat. No.: HY-P1846
CAS No.: 219127-21-6
19
19 Publications Verification
Cat. No.: HY-P1846A
1
1 Cited Publications
Cat. No.: HY-N0819
CAS No.: 89412-79-3
1
1 Cited Publications
Cat. No.: HY-P99121
Target:
Research Areas:
Cat. No.: HY-P99234
CAS No.: 2234335-84-1
Synonyms: IMGN632 Antibody; G4723A
Target:
Research Areas:
Pivekimab (IMGN632 Antibody) is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine (IMGN632), a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) .
Cat. No.: HY-P990068
CAS No.: 2643331-31-9
Synonyms: SRF617
Target:
Research Areas:
Cat. No.: HY-148511
CAS No.: 147063-80-7
Synonyms: CMP-001
Research Areas:
Vidutolimod (CMP-001) is a virus-like particle containing a TLR9 activator . Vidutolimod induces human peripheral blood mononuclear cells to secrete IFNα, and upregulates the gene expression of CXCL10, PDL1, IDO and CD80. Vidutolimod activates TLR9, which in turn triggers plasmacytoid dendritic cell activation, production of IFNγ and TNFα, induction of CXCL10, and recruitment of antitumor T cells. Vidutolimod causes influenza-like symptoms, hypotension and tumor regression, and its activity depends on the presence of anti-Qβ antibodies. Vidutolimod modulates monocyte function, promotes CD4 T cell proliferation, and activates multiple immune cell types in an environment with anti-Qβ antibodies. Vidutolimod prolongs the survival of tumor-bearing mice. Vidutolimod is used in research related to advanced melanoma, head and neck squamous cell carcinoma, and advanced non-small cell lung cancer .
Synonyms: 1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine; 19:0 Lyso PC
Target:
Research Areas:
Lysophosphatidylcholine C19:0 (19:0 Lyso PC) is a lysophosphatidylcholine with a fully saturated C19 acyl chain. When combined with LPS (HY-D1056), Lysophosphatidylcholine C19:0 induces the secretion of IL-1β by human monocyte-derived dendritic cells. Lysophosphatidylcholine C19:0 reduces the viability of monocyte-derived dendritic cells .
Cat. No.: HY-162735
Target:
Research Areas:
BRD5080 is a GPR65 agonist. BRD5080 activates GPR65 to enhance the cAMP signaling pathway, reduce the expression of inflammatory cytokines and chemokines in dendritic cells, enhance the activity of human wild-type, mouse wild-type, and human GPR65 I231L variant receptors in a pH-dependent manner, and mediate the recruitment of Gαs protein. BRD5080 can be used in the research of inflammatory bowel disease .
Cat. No.: HY-P990670
CAS No.: 2935496-38-9
Synonyms: Eltivutabart
Target:
Research Areas:
TTX-030 (Eltivutabart) is a monoclonal antibody that allosterically inhibits CD39 ectonucleotidase activity, preventing the conversion of ATP to AMP. TTX-030 acts as a non-competitive allosteric CD39 ATPase inhibitor, binding to an N-terminal epitope distant from the active site and blocking nucleotide hydrolysis. TTX-030 has an IC50 of 0.20 nM, a Kd of 1.5 nM, and a Ki of 0.5 nM for human CD39. TTX-030 enhances CD4 + and CD8 + T cell proliferation, Th1 cytokine production, T cell function, dendritic cell maturation, and inflammasome activation. TTX-030 can be used in research on human B cell lymphoma and cancer .
Cat. No.: HY-P991193
Target:
Research Areas:
Target:
Research Areas:
CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice .
Cat. No.: HY-P2114
CAS No.: 173959-12-1
Target:
Research Areas:
Cat. No.: HY-108661A
Purity: 97.4%
Target:
Research Areas:
NF546 (hydrate) is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 (hydrate) stimulates release of interleukin-8 from human monocyte-derived dendritic cells .
Cat. No.: HY-145491
CAS No.: 578008-43-2
Cat. No.: HY-P991525
CAS No.: 2923542-55-4
Target:
Research Areas:
Cat. No.: HY-108661
CAS No.: 1006028-37-0
Target:
Research Areas:
NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells .
Cat. No.: HY-14750
CAS No.: 872178-65-9
Synonyms: ROB-803
Target:
Research Areas:
Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation. Rabeximod (ROB-803) is used for rheumatoid arthritis (RA) research .
Cat. No.: HY-178672
CAS No.: 400806-46-4
Synonyms: Anti-Reverse cap analog; m2 7,3′O GpppG
Target:
ARCA (Anti-Reverse cap analog; m2 7,3'OGpppG) is a 5′-cap analog. ARCA carries a methyl group at the 3'-OH position of m7G, which ensures that the cap is ligated to the 5' end of mRNA in the correct orientation during in vitro transcription and prevents reverse ligation. ARCA enhances the translation efficiency and stability of mRNA. In human immature dendritic cells, both the translation efficiency and total protein expression of ARCA-capped mRNA are higher than those of conventional m7GpppG-capped mRNA. ARCA can be used in research related to cancer, infectious diseases and mRNA vaccines .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
