14

ODQ

14 Publications Verification

Cat. No.: HY-101255

CAS No.: 41443-28-1

Purity: 99.75%

Target:

Guanylate Cyclase Apoptosis

Research Areas:

Cancer

ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells .

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5

SGC-CK2-1

5 Cited Publications

Cat. No.: HY-139004

CAS No.: 2470424-39-4

Purity: 99.67%

Target:

Casein Kinase

Research Areas:

Neurological Disease

SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC₅₀s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases .

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1

BAY-678

1 Cited Publications

Cat. No.: HY-111457A

CAS No.: 675103-36-3

Purity: 99.59%

Target:

Elastase

Research Areas:

Inflammation/Immunology

BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

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1

NS-2028

1 Cited Publications

Cat. No.: HY-12379

CAS No.: 204326-43-2

Purity: 99.58%

Target:

Guanylate Cyclase

Research Areas:

Inflammation/Immunology

NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC₅₀ values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity . NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC₅₀ values of 17 nM and 20 nM . NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC₅₀ of 30 nM . NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM) . NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability .

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1

Olinciguat

1 Cited Publications

Cat. No.: HY-109066

CAS No.: 1628732-62-6

Purity: 98.44%

Synonyms: IW-1701

Target:

Guanylate Cyclase

Research Areas:

Cardiovascular Disease

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay .

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1

THPP-1

1 Cited Publications

Cat. No.: HY-117604

CAS No.: 1257051-63-0

Purity: 98.75%

Target:

Phosphodiesterase (PDE)

Research Areas:

Neurological Disease

THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with K_i values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species .

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1

BAY-677

1 Cited Publications

Cat. No.: HY-111457

CAS No.: 2117404-84-7

Purity: 98.02%

Target:

Elastase

Research Areas:

Inflammation/Immunology

BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM . BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC) .

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SGC-NSP2hel-1

Cat. No.: HY-176268

Synonyms: RA-0188293; RA-NSP2-1

Target:

DNA/RNA Synthesis Virus Protease Flavivirus

Research Areas:

Infection

SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC₅₀ > 250 μM. SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease.

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SGC-CK1γ-1

Cat. No.: HY-178335

CAS No.: 3125107-49-2

Target:

LDLR Wnt CMV

Research Areas:

Infection

SGC-CK1γ-1 is a potent and selective probe for the CK1γ subfamily. SGC-CK1γ-1 can inhibit LRP6 phosphorylation levels. SGC-CK1γ-1 can selectively inhibit the CK1γ kinases in living cells and inhibit both WNT signaling and human cytomegalovirus (CMV) replication. SGC-CK1γ-1 can be used for the research of infection .

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UBD1031

Cat. No.: HY-172193

Synonyms: sGC-UBD1031

Target:

Deubiquitinase HDAC

Research Areas:

Inflammation/Immunology Cancer

UBD1031 (SGC-UBD1031) is a selective USP16/HDAC6-UBD antagonist with a human USP16-UBD IC₅₀ of 10.6 μM, K_D value of 48 nM, and a human HDAC6-UBD K_D of 16 nM. UBD1031 disrupts ISG15 C-terminus interactions with USP16-UBD and HDAC6-UBD, and exhibits cooperative inhibition of full-length USP16 deubiquitinase activity via USP16-UBD binding. UBD1031 can be used in research on cancer, autoimmune diseases, and Down syndrome .

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sgc8c aptamer sodium

DNA, 5'-ATCTAACTGCTGCGCCGCCGGGAAAATACTGTACGGTTAGA-3', sodium salt

Cat. No.: HY-160065

sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. sgc8c aptamer sodium can precisely bring the nanotags connected to it to the surface of cells expressing PTK-7, thus achieving specific recognition and labeling of target cells .

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BAY-678 racemate

Cat. No.: HY-111515

CAS No.: 675103-35-2

Target:

Elastase

Research Areas:

Inflammation/Immunology

BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

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GL-1196

Cat. No.: HY-124398

CAS No.: 591242-70-5

Target:

PAK

Research Areas:

Cancer

GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research .

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FAM-sgc8c aptamer sodium

Cat. No.: HY-160065F

FAM-sgc8c aptamer sodium is a 5-FAM labeled sgc8c aptamer sodium (HY-160065). sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. Binding of FAM-sgc8c aptamer sodium to PTK-7 induces the assembly of nanotags on the cell surface, resulting in strong fluorescence and SERS signals .

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ODQ (Standard)

Cat. No.: HY-101255R

CAS No.: 41443-28-1

Target:

Reference Standards Guanylate Cyclase Apoptosis

Research Areas:

Cancer

ODQ (Standard) is the analytical standard of ODQ. This product is intended for research and analytical applications. ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells .

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Olinciguat (Standard)

Cat. No.: HY-109066R

CAS No.: 1628732-62-6

Synonyms: IW-1701 (Standard)

Target:

Reference Standards Guanylate Cyclase

Research Areas:

Cardiovascular Disease

Olinciguat (Standard) is the analytical standard of Olinciguat (HY-109066). This product is intended for research and analytical applications. Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay .

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Sgc8c Aptamer

Cat. No.: HY-177870

Sgc8c Aptamer is a single-stranded DNA aptamer targeting protein tyrosine kinase 7 (PTK7) with K_d of 1.03-11.73 nM for human, mice, rat and monkey. Sgc8c Aptamer can be used to synthesize aptamer-drug conjugates and can be used for cancer research .

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BAY-678 (Standard)

Cat. No.: HY-111457AR

CAS No.: 675103-36-3

Target:

Reference Standards Elastase

Research Areas:

Inflammation/Immunology

BAY-678 (Standard) is the analytical standard of BAY-678 (HY-111457A). This product is intended for research and analytical applications. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

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