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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
hydroxylation activity
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "hydroxylation activity" in MCE Product Catalog:
23
23 Publications Verification
Cat. No.: HY-17508
CAS No.: 81103-11-9
Target:
Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
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1 Cited Publications
Cat. No.: HY-17508R
CAS No.: 81103-11-9
Clarithromycin (Standard) is the analytical standard of Clarithromycin. This product is intended for research and analytical applications. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM . Clarithromycin significantly inhibits the HERG potassium current .Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K .
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Research Areas:
Doxylamine succinate is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine succinate is orally active, possessing analgesic and hypnotic activities. Doxylamine succinate enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine succinate decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine succinate induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine succinate can be used for the research of nausea, allergy, insomnia .
Cat. No.: HY-113482
CAS No.: 80434-32-8
Synonyms: 1β-OH-DCA
Cat. No.: HY-17508S1
CAS No.: 959119-22-3
Cat. No.: HY-154825
CAS No.: 651734-12-2
Synonyms: 20(OH)D3; 20S-Hydroxyvitamin D3
Research Areas:
20-Hydroxyvitamin D3 (20(OH)D3), a product of vitamin D3 hydroxylation, is a noncalcemic immunomodulator. 20-Hydroxyvitamin D3 binds to vitamin D receptor (VDR), activates VDR and aryl hydrocarbon receptor (AhR) signaling, stimulates CYP24A1 expression, and drives VDR nuclear translocation. 20-Hydroxyvitamin D3 inhibits NF-κB activity via IκBα upregulation. 20-Hydroxyvitamin D3 acts as a substrate for CYP27B1 and rat CYP24A1, undergoing hydroxylation to form dihydroxy-derivatives. 20-Hydroxyvitamin D3 inhibits cell proliferation, colony formation, migration, and tumor growth, and induces cell differentiation in cancer cells. 20-Hydroxyvitamin D3 can be used for the research of inflammatory and autoimmune diseases, melanoma, breast carcinomas, and hepatocarcinoma .
Cat. No.: HY-N7697E
CAS No.: 117436-78-9
Target:
Cat. No.: HY-N7372
CAS No.: 66067-26-3
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Isoflavanones Glycyrrhiza uralensis Fisch. Extract Other Diseases Phenols Polyphenols Disease Research Fields
Target:
Cat. No.: HY-N9434
CAS No.: 82475-00-1
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Flavones Dalbergia odorifera T. Chen Extract
Target:
Cat. No.: HY-113322
CAS No.: 53467-23-5
Synonyms: 3-Hydroxyquinidine
Target:
Research Areas:
3-Hydroxyquinine (3-Hydroxyquinidine) is the major metabolite of Quinine (HY-D0143) and a biomarker of CYP3A4 activity. 3-Hydroxyquinine is formed through CYP3A4-mediated 3-hydroxylation catalyzed by CYP3A isoforms .
Target:
Research Areas:
Doxylamine is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine is orally active, possessing analgesic and hypnotic activities. Doxylamine enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine can be used for the research of nausea, allergy, insomnia .
Research Areas:
Doxylamine succinate (Standard) is the analytical standard of Doxylamine succinate (HY-A0069). This product is intended for research and analytical applications. Doxylamine succinate is a first-generation antihistamine and acts as a histamine H1 receptor antagonist. Doxylamine succinate is orally active, possessing analgesic and hypnotic activities. Doxylamine succinate enhances the activities of CYP2B, CYP2A, CYP3A and thyroxine-glucuronosyltransferase via promoting substrate hydroxylation and thyroxine metabolic pathways. Doxylamine succinate decreases serum thyroxine (T4) level and elevates serum thyroid-stimulating hormone (TSH) level. Doxylamine succinate induces liver enlargement and increases the activities of hepatic microsomal cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase. Doxylamine succinate can be used for the research of nausea, allergy, insomnia .
Cat. No.: HY-121057
CAS No.: 67739-71-3
Synonyms: 3-OH FNTZ
Target:
Research Areas:
3-Hydroxyflunitrazepam (3-OH FNTZ) is the major metabolite of Flunitrazepam (FNTZ), generated via 3-hydroxylation by CYP3A4 (Km = 286 μM), and represents the dominant metabolic pathway (>80%) in liver microsomes. Its formation is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole (HY-B0105) (IC50 = 0.11 μM) and Ritonavir (HY-90001) (IC50 = 0.041 μM), indicating a strong dependence on CYP3A4 activity and potential drug interactions .
Cat. No.: HY-113020R
CAS No.: 1164-98-3
Category:
Cat. No.: HY-A0069AS
CAS No.: 1173020-59-1
Cat. No.: HY-A0069S
CAS No.: 1216840-94-6
Cat. No.: HY-113482S
Synonyms: 1β-OH-DCA-d5
Research Areas:
1β-Hydroxydeoxycholic acid-d5 (1β-OH-DCA-d5) is the deuterated-labeled 1β-Hydroxydeoxycholic acid (HY-113482). 1β-Hydroxydeoxycholic acid (1β-OH-DCA) is an endogenous bile acid metabolite formed from deoxycholic acid via CYP3A-mediated 1β-hydroxylation. 1β-Hydroxydeoxycholic acid undergoes rapid metabolism in human hepatocytes, primarily through glycine conjugation to form G-1β-OH-DCA, with minor taurine conjugation and sulfation. The urinary ratio of 1β-Hydroxydeoxycholic acid to deoxycholic acid can be used as an endogenous biomarker for assessing CYP3A activity. 1β-Hydroxydeoxycholic acid can be used in metabolism-related research .
Cat. No.: HY-E71368
Target:
Research Areas:
17α-Hydroxyprogesterone deacetylase (EC 1.14.14.32) is a cytochrome P450 enzyme that exhibits 17,20-lyase activity. It participates in catalyzing the 17-hydroxylation of pregnenolone and progesterone.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
